ArticleToxicology letters2010
Differential immunotoxic effects of inorganic and organic mercury species in vitro.
Article in Toxicology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mercury Exposure and Heart Rate Variability: a Systematic Review.Current environmental health reports · 2015Pooled it
- Regulatory T Cells and IFNγ in Mercury-Induced Autoimmunity: Insights from Adoptive Transfer in B10.S Mice.Biology · 2026Article
- Environmental Risk Factors for Systemic Lupus Erythematosus Through the Lens of Social Determinants of Health.Arthritis care & research · 2025Review
- Association between heavy metal exposure and biomarkers for non-alcoholic fatty liver disease in Korean adolescents.Heliyon · 2024Article
- The association between heavy metal exposure and obesity: A systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2024Review
- Review
- Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3-4 (2015-2020).Scientific reports · 2024Article
- Higher blood manganese level associated with increased risk of adult latent tuberculosis infection in the US population.Frontiers in public health · 2024Article
- Associations of exposure to blood heavy metal mixtures withFrontiers in public health · 2024Article
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- The role of environmental exposures and gene-environment interactions in the etiology of systemic lupus erythematous.Journal of internal medicine · 2022Review
- Serum cytokines are associated with n-3 polyunsaturated fatty acids and not with methylmercury measured in infant cord blood in the Seychelles child development study.Environmental research · 2022Article
- Fluorescence Based Comparative Sensing Behavior of the Nano-Composites of SiONanomaterials (Basel, Switzerland) · 2021Article
- Ocular Surface Pathology in Patients Suffering from Mercury Intoxication.Diagnostics (Basel, Switzerland) · 2021Article
- Comparative Evaluation of the Cytotoxicity of Glyphosate-Based Herbicides and Glycine in L929 and Caco2 Cells.Frontiers in public health · 2021Article
- Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents.Environmental science and pollution research international · 2019Article
- Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Modulators of mercury risk to wildlife and humans in the context of rapid global change.Ambio · 2018Article
- Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans.DNA repair · 2017Article
- Children's white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant contributors to human disease as well as mechanistically relevant to other target organ toxicities. In this study, we compared the effects of inorganic Hg (iHg) to organic Hg species (MeHg and ethylmercury, EtHg) in human peripheral blood mononuclear cells (PBMCs) in vitro at sub-cytotoxic concentrations, using methods developed to characterize response of human PBMCs to iHg in vitro. PBMCs were isolated from six volunteer blood donors (three males and three females) and cultured in the presence and absence of lipopolysaccharide (LPS) and low levels (up to 200nM of each Hg species, separately) for 24h in culture. Cell culture supernatants were analyzed for cytokine concentrations with a bead-based multiplex assay. We report that iHg and MeHg both increase pro-inflammatory cytokine release in LPS-stimulated PBMCs, while EtHg decreases IFN-gamma release as well pro-inflammatory cytokine release. IL-17 release is significantly increased only in response to iHg treatment. Levels of anti-inflammatory cytokines (IL-1Ra and IL-10) were not significantly altered by any Hg treatment. These results indicate that both organic and inorganic species of Hg can affect the human immune system, but that they may exert different effects on immune function.
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