ArticleGene2010
Origin and evolution of LINE-1 derived "half-L1" retrotransposons (HAL1).
Article in Gene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- LINE-1 Retrotransposition Assays in Embryonic Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- LINE-1 and Alu methylation signatures in autism spectrum disorder and their associations with the expression of autism-related genes.Scientific reports · 2022Article
- Identification and characterization of satellite DNAs in two-toed sloths of the genus Choloepus (Megalonychidae, Xenarthra).Scientific reports · 2020Article
- Review
- LINEs Contribute to the Origins of Middle Bodies of SINEs besides 3' Tails.Genome biology and evolution · 2018Article
- Roles for retrotransposon insertions in human disease.Mobile DNA · 2016Review
- A 3' Poly(A) Tract Is Required for LINE-1 Retrotransposition.Molecular cell · 2015Article
- A New Class of SINEs with snRNA Gene-Derived Heads.Genome biology and evolution · 2015Article
- Ancient traces of tailless retropseudogenes in therian genomes.Genome biology and evolution · 2015Article
- Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.PLoS genetics · 2014Article
- Homologues of bacterial TnpB_IS605 are widespread in diverse eukaryotic transposable elements.Mobile DNA · 2013Article
- Evolution of a transposon in Daphnia hybrid genomes.Mobile DNA · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
LINE-1 (L1) retrotransposons represent the most abundant family of non-LTR retrotransposons in virtually all mammals. The only currently known exception is Platypus, where it is found only in low copy numbers. Autonomous L1s encode two proteins, ORF1p and ORF2p, both of which are required for the transposition of L1s. L1 replicative machinery is also involved in the trans-mobilization of non-autonomous retrotransposons, such as diverse short interspersed repetitive elements (SINEs) and processed pseudogenes. Here, we focus on a unique category of "half -L1" elements (HAL1s), which encode ORF1p but not ORF2p. HAL1s are present both in placental mammals and marsupials. We demonstrate that HAL1s originated independently several times during the evolution of mammals. The youngest mammalian HAL1 elements analyzed in this paper were identified in the guinea pig genome. Our analysis strongly suggests that HAL1-encoded ORF1p is essential for the transposition of HAL1s and indicates that the evolution of ORF1p in HAL1s is faster than in L1s. The implications of HAL1 for the evolution of L1 elements and the host genomes are discussed.
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