ArticleExperimental hematology2010
Synchrony of telomere length among hematopoietic cells.
Article in Experimental hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
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Who cites it
94 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.Human molecular genetics · 2012Pooled it
- Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study.Psychosomatic medicine · 2018Trial
- Maternal health behavior during pregnancy mediates the relationship between maternal stress and newborn telomere length.Brain, behavior, & immunity - health · 2026Article
- Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.bioRxiv : the preprint server for biology · 2026Article
- Telomerase activity in T-cells as a functional test for pathogenicity assessment of novel genetic variants in telomere biology disorders.Scientific reports · 2025Article
- Long donor leukocyte telomeres raise risk of severe COVID-19 in recipients of allogeneic hematopoietic cell transplant.Frontiers in immunology · 2025Article
- Association of ageing-related biomarkers with peripheral neuropathy in colorectal cancer patients up to 2 years after diagnosis.PloS one · 2025Article
- Methods for telomere length measurement: an update on current technologies and emerging approaches.Frontiers in molecular biosciences · 2025Review
- Mode of delivery predicts postpartum maternal leukocyte telomere length.European journal of obstetrics, gynecology, and reproductive biology · 2024Article
- No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep.Proceedings. Biological sciences · 2024Article
- T-cell count and T-cell telomere length in patients with severe COVID-19.Frontiers in immunology · 2024Article
- Article
- Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training.Aging cell · 2023Review
- Article
- The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective.GeroScience · 2023Article
- Telomere dysfunction in some pediatric congenital and growth-related diseases.Frontiers in pediatrics · 2023Review
- Telomere length declines with age, but relates to immune function independent of age in a wild passerine.Royal Society open science · 2022Article
- Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort.Aging · 2022Article
- Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
objectiveLittle is known about the relationship of telomere length among leukocyte subsets and cells up the hematopoietic hierarchy. This information is relevant because telomere dynamics in granulocytes were postulated to mirror those of hematopoietic stem cells (HSCs). MATERIALS AND
methodsIn newborn umbilical cord blood (UCB), we examined the relationships of telomere length in hematopoietic progenitor cells (HPCs) (CD34(+)CD45(-)) with those in T lymphocytes and granulocytes. In addition, we correlated telomere length in granulocytes with those in whole leukocyte samples of individuals ranging in age from birth to 100 years.
resultsIn the UCB, we found strong correlations of telomere length in HPCs with telomere length in T lymphocytes (r ranging from 0.882 to 0.935; p ranging from 0.0038 to 0.0007) and in granulocytes (r = 0.930; p = 0.0072). At birth, strong correlations were also observed between telomere length in granulocytes and those in all leukocytes (r = 0.979; p = 0.0003). Throughout the human lifespan, the relationship between telomere length in granulocytes and that in all leukocytes was r > 0.980 and p < 0.0001.
conclusionsRobust synchrony exists among leukocyte subsets throughout the human lifespan; individuals with relatively long (or short) telomeres in one leukocyte subset have long (or short) telomeres in other leukocyte subsets. Moreover, telomere length in leukocytes reflects its length in cells up the hematopoietic hierarchy, i.e., HPCs and, by inference, HSCs. Strong links have been found by many studies between leukocyte telomere length and a host of aging-related diseases. Our findings suggest, therefore, that these links might be traced to telomere dynamics in HSCs.
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