ArticleJournal of neuroscience methods2010
Cross-correlation of instantaneous amplitudes of field potential oscillations: a straightforward method to estimate the directionality and lag between brain areas.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 112 citations in OpenAlex.
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- Homeostatic coupling of cortical and brainstem delta rhythms in sleeping infant rats.bioRxiv : the preprint server for biology · 2026Article
- Acute ethanol enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging.Alcohol (Fayetteville, N.Y.) · 2026Article
- [Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Prioritized learning of cross-population neural dynamics.Journal of neural engineering · 2025Article
- Multi-regional control of amygdalar dynamics reliably reflects fear memory age.Nature communications · 2024Article
- Perineuronal Nets in the Rat Medial Prefrontal Cortex Alter Hippocampal-Prefrontal Oscillations and Reshape Cocaine Self-Administration Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multi-scale dynamics by adjusting the leaking rate to enhance the performance of deep echo state networks.Frontiers in artificial intelligence · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures.Hippocampus · 2023Article
- Theta coupling within the medial prefrontal cortex regulates fear extinction and renewal.iScience · 2022Article
- Advances in human intracranial electroencephalography research, guidelines and good practices.NeuroImage · 2022Review
- Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.Neuron · 2022Article
- Dissociable oscillatory theta signatures of memory formation in the developing brain.Current biology : CB · 2022Article
- Acquiring new memories in neocortex of hippocampal-lesioned mice.Nature communications · 2022Article
- Localizing Spectral Interactions in the Resting State Network Using the Hilbert-Huang Transform.Brain sciences · 2022Article
- Article
- Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments.Epilepsia · 2021Article
- Cross-population coupling of neural activity based on Gaussian process current source densities.PLoS computational biology · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Researchers performing multi-site recordings are often interested in identifying the directionality of functional connectivity and estimating lags between sites. Current techniques for determining directionality require spike trains or involve multivariate autoregressive modeling. However, it is often difficult to sample large numbers of spikes from multiple areas simultaneously, and modeling can be sensitive to noise. A simple, model-independent method to estimate directionality and lag using local field potentials (LFPs) would be of general interest. Here we describe such a method using the cross-correlation of the instantaneous amplitudes of filtered LFPs. The method involves four steps. First, LFPs are band-pass filtered; second, the instantaneous amplitude of the filtered signals is calculated; third, these amplitudes are cross-correlated and the lag at which the cross-correlation peak occurs is determined; fourth, the distribution of lags obtained is tested to determine if it differs from zero. This method was applied to LFPs recorded from the ventral hippocampus and the medial prefrontal cortex in awake behaving mice. The results demonstrate that the hippocampus leads the mPFC, in good agreement with the time lag calculated from the phase locking of mPFC spikes to vHPC LFP oscillations in the same dataset. We also compare the amplitude cross-correlation method to partial directed coherence, a commonly used multivariate autoregressive model-dependent method, and find that the former is more robust to the effects of noise. These data suggest that the cross-correlation of instantaneous amplitude of filtered LFPs is a valid method to study the direction of flow of information across brain areas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.