ArticleDevelopmental and comparative immunology2010
Lipoteichoic acid and lipopolysaccharide can activate antimicrobial peptide expression in the tobacco hornworm Manduca sexta.
Article in Developmental and comparative immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review.International journal of molecular sciences · 2024Review
- Evaluation of Novel HLM Peptide Activity and Toxicity against Planktonic and Biofilm Bacteria: Comparison to Standard Antibiotics.Current protein & peptide science · 2024Article
- Article
- Induced expression modes of genes related to Toll, Imd, and JAK/STAT signaling pathway-mediated immune response inFrontiers in physiology · 2023Article
- Evaluation of antibacterial activity induced bySaudi journal of biological sciences · 2022Article
- Toll9 fromProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance.Cellular and molecular life sciences : CMLS · 2021Review
- A Toll-Spätzle Pathway in the Immune Response ofInsects · 2020Article
- The Tripartite Interaction of Host Immunity-Toxins · 2020Review
- The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance.Research (Washington, D.C.) · 2020Review
- Design and characterization of a new hybrid peptide from LL-37 and BMAP-27.Infection and drug resistance · 2019Article
- Distinct Functions ofFrontiers in immunology · 2019Article
- ProbioticFrontiers in microbiology · 2017Article
- Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta.Scientific reports · 2016Article
- Molecular cloning and characterization of gloverin from the diamondback moth, Plutella xylostella L. and its interaction with bacterial membrane.World journal of microbiology & biotechnology · 2015Article
- The waaL gene mutation compromised the inhabitation of Enterobacter sp. Ag1 in the mosquito gut environment.Parasites & vectors · 2015Article
- Characterization of a novel Manduca sexta beta-1, 3-glucan recognition protein (βGRP3) with multiple functions.Insect biochemistry and molecular biology · 2014Article
- Insect antimicrobial peptides and their applications.Applied microbiology and biotechnology · 2014Review
- Induction of gliotoxin secretion in Aspergillus fumigatus by bacteria-associated molecules.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activation of prophenoloxidase and synthesis of antimicrobial peptides (AMPs) are two important innate immune mechanisms in insects. In the current study, we investigated immune responses activated by three major bacterial components, lipopolysaccharide (LPS) (including rough mutants of LPS), lipoteichoic acid (LTA), and peptidoglycan (PG), in the larvae of a lepidopteran insect, Manduca sexta. We found that two DAP (diaminopimelic acid)-type PGs from Escherichia coli and Bacillus subtilis were much more potent than LPS and LTA from the respective bacteria as well as a Lysine-type PG in activation of prophenoloxidase in M. sexta larval plasma in vitro. Transcription levels of AMP genes, such as Attacin, Lebocin and Moricin genes, in the hemocytes and fat body of larvae were significantly induced by smooth LPS (TLR4grade) and rough mutants of LPS (TLRgrade), synthetic lipid A, LTA, and PG. LPS from E. coli and LTA from B. subtilis activated AMP expression to significantly higher levels than PGs from the respective bacterial strains, and smooth LPS were more potent than lipid A and rough mutants of LPS in activation of AMP expression. Our results demonstrated for the first time that LTA can activate AMP expression, and different moieties of LPS may synergistically activate AMP expression in M. sexta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.