ReviewPharmacology, biochemistry, and behavior2010
Neuropharmacology of learned flavor preferences.
Review in Pharmacology, biochemistry, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Non-nutritive sweeteners attenuate reinforced cephalic phase insulin release and impair glucose tolerance in mice.The journal of physiological sciences : JPS · 2026Article
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- Trends and Associations of Menthol Cigarette Smoking Among US Middle and High School Students-National Youth Tobacco Survey, 2011-2018.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents.Drug and alcohol dependence · 2019Article
- Facilitation and retardation of flavor preference conditioning following prior exposure to the flavor conditioned stimulus.Learning & behavior · 2019Article
- How and why do gastrointestinal peptides influence food intake?Physiology & behavior · 2018Review
- Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats.Neural plasticity · 2017Article
- Motivational state, reward value, and Pavlovian cues differentially affect skilled forelimb grasping in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The Involvement of the T1R3 Receptor Protein in the Control of Glucose Metabolism in Mice at Different Levels of Glycemia.Journal of evolutionary biochemistry and physiology · 2014Article
- Effect of dopamine D1 and D2 receptor antagonism in the lateral hypothalamus on the expression and acquisition of fructose-conditioned flavor preference in rats.Brain research · 2014Article
- Gut-brain nutrient signaling. Appetition vs. satiation.Appetite · 2013Review
- "Jello® shots" and cocktails as ethanol vehicles: parametric studies with high- and low-saccharin-consuming rats.Nutrients · 2013Article
- Glucose utilization rates regulate intake levels of artificial sweeteners.The Journal of physiology · 2013Article
- Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior.Neuroscience and biobehavioral reviews · 2013Review
- Metabolic regulation of brain response to food cues.Current biology : CB · 2013Article
- Altered processing of sweet taste in the brain of diet soda drinkers.Physiology & behavior · 2012Article
- Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association.Diabetes care · 2012Article
- Taste uncoupled from nutrition fails to sustain the reinforcing properties of food.The European journal of neuroscience · 2012Article
- Mechanisms for sweetness.The Journal of nutrition · 2012Review
- Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues.Synapse (New York, N.Y.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Innate and learned flavor preferences influence food and fluid choices in animals. Two primary forms of learned preferences involve flavor-flavor and flavor-nutrient associations in which a particular flavor element (e.g., odor) is paired with an innately preferred flavor element (e.g., sweet taste) or with a positive post-oral nutrient consequence. This review summarizes recent findings related to the neurochemical basis of learned flavor preferences. Systemic and central injections of dopamine receptor antagonists implicate brain dopamine signaling in both flavor-flavor and flavor-nutrient conditioning by the taste and post-oral effects of sugars. Dopamine signaling in the nucleus accumbens, amygdala and lateral hypothalamus is involved in one or both forms of conditioning and selective effects are produced by D1-like and D2-like receptor antagonism. Opioid receptor antagonism, despite its suppressive action on sugar intake and reward, has little effect on the acquisition or expression of flavor preferences conditioned by the sweet taste or post-oral actions of sugars. Other studies indicate that flavor preference conditioning by sugars is differentially influenced by glutamate receptor antagonism, cannabinoid receptor antagonism and benzodiazepine receptor activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.