ArticlePharmacology, biochemistry, and behavior2010
Forced swim test behavior in postpartum rats.
Article in Pharmacology, biochemistry, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring.IBRO neuroscience reports · 2024Article
- Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice.The international journal of neuropsychopharmacology · 2023Article
- Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.Neuroendocrinology · 2023Article
- Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.Hormones and behavior · 2021Article
- Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Postpartum changes in affect-related behavior and VTA dopamine neuron activity in rats.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Sex-Dependent Effects of Stress on Immobility Behavior and VTA Dopamine Neuron Activity: Modulation by Ketamine.The international journal of neuropsychopharmacology · 2017Article
- Treadmill exercise ameliorates depressive symptoms through increasing serotonin expression in postpartum depression rats.Journal of exercise rehabilitation · 2017Article
- Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner.Scientific reports · 2016Article
- An investigation into the effects of antenatal stressors on the postpartum neuroimmune profile and depressive-like behaviors.Behavioural brain research · 2016Article
- Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammals.Hormones and behavior · 2015Review
- Shen-Qi-Jie-Yu-Fang has antidepressant effects in a rodent model of postpartum depression by regulating the immune organs and subsets of T lymphocytes.Neuropsychiatric disease and treatment · 2015Article
- Article
- Emotion and mood adaptations in the peripartum female:complementary contributions of GABA and oxytocin.Journal of neuroendocrinology · 2014Review
- Sex differences in animal models of psychiatric disorders.British journal of pharmacology · 2014Review
- The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Behavioral and neuronal biochemical possible effects in experimental induced chronic mild stress in male albino rats under the effect of oral barley administration in comparison to venlafaxine.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Chronic cocaine exposure during pregnancy increases postpartum neuroendocrine stress responses.Journal of neuroendocrinology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This study was undertaken to determine whether depression-like behavior can be observed in gonadally intact females that have experienced normal pregnancy. When tested on the forced swim test (FST) on postpartum days 1-7, previously pregnant rats spent slightly more time immobile, significantly less time swimming and diving, and defecated more than virgin controls. Subchronic treatment with nomifensine (DA reuptake inhibitor, 2.5mg/kg) but not sertraline (serotonin reuptake inhibitor, 10mg/kg) or desipramine (norepinephrine reuptake inhibitor, 10mg/kg) significantly decreased immobility on postpartum day 2. In rats pre-exposed to the FST in mid-pregnancy, neither subchronic nor chronic treatment with desipramine or sertraline decreased immobility on postpartum day 2; in contrast, chronic desipramine significantly decreased immobility in virgin controls. These results indicate that postpartum female rats, compared to virgin controls, show a reduction in some "active coping behaviors" but no significant increase in immobility when tested during the early postpartum period, unlike ovariectomized females that have undergone hormone-simulated pregnancy (HSP). Additionally, immobility that is increased by FST pre-exposure is not readily prevented by treatment with standard antidepressant medications in postpartum females. Depression-like behaviors previously observed in females that have undergone HSP may result from the more dramatic changes in estradiol, prolactin or corticosterone that occur during the early "postpartum" period, compared to the more subtle changes in these hormones that occur in actual postpartum females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.