ArticlePhysiology & behavior2010
Differential effects of sucrose and fructose on dietary obesity in four mouse strains.
Article in Physiology & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
- A consensus guide to preclinical indirect calorimetry experiments.Nature metabolism · 2025Review
- Multitissue single-cell analysis reveals differential cellular and molecular sensitivity between fructose and high-fat high-sucrose diets.Cell reports · 2025Article
- Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation.PLoS genetics · 2023Article
- Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.The Journal of nutritional biochemistry · 2023Review
- Article
- Differential effects of acute versus chronic dietary fructose consumption on metabolic responses in FVB/N mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Protein Amount, Quality, and Physical Activity.Nutrients · 2021Article
- Disparate Metabolomic Responses to Fructose Consumption between Different Mouse Strains and the Role of Gut Microbiota.Metabolites · 2021Article
- Genetic controls of Tas1r3-independent sucrose consumption in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- A High Fat/High Sugar Diet Alters the Gastrointestinal Metabolome in a Sex Dependent Manner.Metabolites · 2020Article
- Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice.The Journal of nutrition · 2020Article
- Review
- Concurrent and Delayed Behavioral and Monoamine Alterations by Excessive Sucrose Intake in Juvenile Mice.Frontiers in neuroscience · 2020Article
- Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice.Biochimica et biophysica acta. Molecular basis of disease · 2020Article
- Microglia Play an Active Role in Obesity-Associated Cognitive Decline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.Nutrients · 2017Article
- Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress.Nutrients · 2017Article
- Disparate metabolic response to fructose feeding between different mouse strains.Scientific reports · 2015Article
- Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism.Physiology & behavior · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor. The T1R3 receptor in the FVB and B6 strains has a higher affinity for sugars than that in the AKR and 129P3 strains. In Experiment 1, mice had 40days of access to lab chow plus water, sucrose (10 or 34%), or fructose (10 or 34%) solutions. The strains consumed more of the sucrose than isocaloric fructose solutions. The pattern of strain differences in caloric intake from the 10% sugar solutions was FVB>129P3=B6>AKR; and that from the 34% sugar solutions was FVB>129P3>B6>/=AKR. Despite consuming more sugar calories, the FVB mice resisted obesity altogether. The AKR and 129P3 mice became obese exclusively on the 34% sucrose diet, while the B6 mice did so on the 34% sucrose and 34% fructose diets. In Experiment 2, we compared total caloric intake from diets containing chow versus chow plus 34% sucrose. All strains consumed between 11 and 25% more calories from the sucrose-supplemented diet. In Experiment 3, we compared the oral acceptability of the sucrose and fructose solutions, using lick tests. All strains licked more avidly for the 10% sucrose solutions. The results indicate that in mice (a) Tas1r3 genotype does not predict sugar-induced hyperphagia or obesity; (b) sucrose solutions stimulate higher daily intakes than isocaloric fructose solutions; and (c) susceptibility to sugar-induced obesity varies with strain, sugar concentration and sugar type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.