ArticleJournal of molecular biology2010
Positive autoregulation shapes response timing and intensity in two-component signal transduction systems.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The Dynamics of Inducible Genetic Circuits.ArXiv · 2026Article
- The Interplay Between Non-Instantaneous Dynamics of mRNA and Bounded Extrinsic Stochastic Perturbations for a Self-Enhancing Transcription Factor.Entropy (Basel, Switzerland) · 2026Article
- Structural properties and asymptotic behavior of bacterial two-component systems.Frontiers in systems biology · 2025Article
- Chemical Reaction Models in Synthetic Promoter Design in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes.Molecular systems biology · 2023Article
- A balancing act in transcription regulation by response regulators: titration of transcription factor activity by decoy DNA binding sites.Nucleic acids research · 2021Article
- Role of a local transcription factor in governing cellular carbon/nitrogen homeostasis in Pseudomonas fluorescens.Nucleic acids research · 2021Article
- How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression.International journal of molecular sciences · 2020Review
- Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback.Scientific reports · 2020Article
- Article
- Development of Aspirin-Inducible Biosensors inApplied and environmental microbiology · 2019Article
- Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback.Cell reports · 2018Article
- An Essential Regulatory System Originating from Polygenic Transcriptional Rewiring of PhoP-PhoQ ofGenetics · 2017Article
- Feedback Control of Two-Component Regulatory Systems.Annual review of microbiology · 2016Review
- Article
- Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications.Annual review of microbiology · 2013Review
- VirB-mediated positive feedback control of the virulence gene regulatory cascade of Shigella flexneri.Journal of bacteriology · 2012Article
- Speed, sensitivity, and bistability in auto-activating signaling circuits.PLoS computational biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Positive feedback loops are regulatory elements that can modulate expression output, kinetics and noise in genetic circuits. Transcriptional regulators participating in such loops are often expressed from two promoters, one constitutive and one autoregulated. Here, we investigate the interplay of promoter strengths and the intensity of the stimulus activating the transcriptional regulator in defining the output of a positively autoregulated genetic circuit. Using a mathematical model of two-component regulatory systems, which are present in all domains of life, we establish that positive feedback strongly affects the steady-state output levels at both low and high levels of stimulus if the constitutive promoter of the regulator is weak. By contrast, the effect of positive feedback is negligible when the constitutive promoter is sufficiently strong, unless the stimulus intensity is very high. Furthermore, we determine that positive feedback can affect both transient and steady state output levels even in the simplest genetic regulatory systems. We tested our modeling predictions by abolishing the positive feedback loop in the two-component regulatory system PhoP/PhoQ of Salmonella enterica, which resulted in diminished induction of PhoP-activated genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.