ReviewExperimental parasitology2010
Giardia duodenalis: the double-edged sword of immune responses in giardiasis.
Review in Experimental parasitology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 129 citations in OpenAlex.
- Giardia duodenalis infection in the context of a community-based deworming and water, sanitation and hygiene trial in Timor-Leste.Parasites & vectors · 2019Trial
- Pathogenicity and virulence ofVirulence · 2026Review
- Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection.PLoS pathogens · 2026Article
- Unraveling the Potential ofPharmaceutics · 2026Article
- The differential roles of Giardia duodenalis-secreted tenascins in inducing intestinal epithelial cell apoptosis and the attributed EGFR-STAT3 axis regulation.PLoS neglected tropical diseases · 2026Article
- Iron Regulatory Mechanism IRE/IRP-like in Two Protozoa of Importance to Human Health,Pathogens (Basel, Switzerland) · 2026Review
- Unravelling the cellular sources and location of IL-17A production during a Giardia infection.Scientific reports · 2025Article
- Human Giardiasis in Ghana - A Scoping Review of Studies From 2004 to 2024.Health science reports · 2025Article
- Article
- Giardiasis: Report of a Case Refractory to Treatment.Clinical case reports · 2025Article
- The Influence of the ProtozoanInternational journal of molecular sciences · 2024Review
- Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019.Journal of travel medicine · 2024Article
- Trends and clinico-epidemiological profile of patients with Giardiasis: Five-year experience from a university hospital of northern India.Journal of family medicine and primary care · 2023Article
- A shotgun metagenomic analysis of the fecal microbiome in humans infected with Giardia duodenalis.Parasites & vectors · 2023Article
- Ultrastructural changes and IgA modulatory effect of commercial prebiotic and probiotic in murine giardiasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- The Exosome-like Vesicles ofInternational journal of molecular sciences · 2023Article
- Conjugated linoleic acid modifies transcriptional cytokine profile and induces early specific secretory IgA response inIranian journal of basic medical sciences · 2022Article
- The interaction of gut microbiota with parasitic protozoa.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Mucosal Defense AgainstFrontiers in immunology · 2022Review
- Multilocus sequence typing ofFrontiers in medicine · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Giardiasis is one of the most common intestinal protozoan infections worldwide. The etiological agent, Giardia duodenalis (syn. Giardia lamblia, Giardia intestinalis), is a flagellated, binucleated protozoan parasite which infects a wide array of mammalian hosts (Adam, 2001). The symptoms of giardiasis include abdominal cramps, nausea, and acute or chronic diarrhea, with malabsorption and failure of children to thrive occurring in both sub-clinical and symptomatic disease (Thompson et al., 1993). Infections are transmitted by cysts which are excreted in the feces of infected humans and animals. Human giardiasis is distributed worldwide, with rates of detection between 2-5% in the developed world and 20-30% in the developing nations (Farthing, 1994). There is significant variation in the outcome of Giardia infections. Most infections are self-limiting, although re-infection is common in endemic areas and chronic infections also occur. Moreover, some individuals suffer from severe cramps, nausea and diarrhea while others escape these overt symptoms. This review will describe recent advances in parasite genetics and host immunity that are helping to shed light on this variability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.