ArticleChemistry and physics of lipids2010
Effects of the endosomal lipid bis(monoacylglycero)phosphate on the thermotropic properties of DPPC: A 2H NMR and spin label EPR study.
Article in Chemistry and physics of lipids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Rapidly Screening the Correlation between the Rotational Mobility and the Hydrogen Bonding Strength of Confined Water.The journal of physical chemistry. B · 2024Article
- Spatiotemporally controlled drug delivery via photothermally driven conformational change of self-integrated plasmonic hybrid nanogels.Journal of nanobiotechnology · 2023Article
- Nucleic Acid-Loaded Lipid Nanoparticle Interactions with Model Endosomal Membranes.ACS applied materials & interfaces · 2022Article
- Life in the lumen: The multivesicular endosome.Traffic (Copenhagen, Denmark) · 2020Review
- Effect of lipid headgroup charge and pH on the stability and membrane insertion potential of calcium condensed gene complexes.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH.PloS one · 2014Article
- Lipid sorting and multivesicular endosome biogenesis.Cold Spring Harbor perspectives in biology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Bis(monoacylglycero)phosphate (BMP) is an endosomal lipid with a unique structure that is implicated in the formation of intraendosomal vesicular bodies. Here we have characterized the effects of dioleoyl-BMP (BMP(18:1)) at concentrations of 5, 10, 15 and 20mol% on the thermotropic behavior of dipalmitoyl phosphatidylcholine (DPPC) vesicles, and compared them to those of equimolar concentrations of dioleoyl phosphatidylglycerol (DOPG), a structural isoform of BMP(18:1). Because BMP is found in the acidic environments of the late endosome and intralysosomal vesicles, samples were prepared at pH 4.2 to mimic the pH of the lysosome. Both (2)H NMR of perdeuterated DPPC and spin-labeled EPR with 16-doxyl phosphatidylcholine were utilized in these investigations. NMR and EPR results show that BMP(18:1) induces a lowering in the main phase transition temperature of DPPC similar to that of DOPG. The EPR studies reveal that BMP(18:1) induced more disorder in the L(beta) phase when compared to equimolar concentrations of DOPG. Analysis from dePaked (2)H NMR spectra in the L(alpha) phase reveals that BMP(18:1) induces less disorder than equal concentrations of DOPG. Additionally, the results demonstrate that BMP mixes with other phospholipids as a phospholipid and not as a detergent molecule as once speculated.
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Registered trials
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