ArticleBiochemical pharmacology2010
Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion.
Article in Biochemical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Bidirectional transfer of pritelivir across term human placenta and its effect on placental functions.The Journal of pharmacology and experimental therapeutics · 2025Article
- Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain.European journal of drug metabolism and pharmacokinetics · 2023Article
- Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiOParticle and fibre toxicology · 2020Article
- Racial association and pharmacotherapy in neonatal opioid withdrawal syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2019Observational
- Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines.Drug metabolism letters · 2019Article
- Placental control of drug delivery.Advanced drug delivery reviews · 2017Review
- Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.Pharmaceutical research · 2016Review
- Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.Clinical pharmacokinetics · 2016Review
- Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid.American journal of obstetrics and gynecology · 2016Article
- ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord.Xenobiotica; the fate of foreign compounds in biological systems · 2016Article
- Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport.Pharmaceutical research · 2015Article
- Metabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus).Drug metabolism and disposition: the biological fate of chemicals · 2014Article
- Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring.Journal of clinical psychopharmacology · 2014Review
- Enhanced brain disposition and effects of Δ9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cigarette smoking during pregnancy is a preventable risk factor associated with maternal and fetal complications. Bupropion is an antidepressant used successfully for smoking cessation in non-pregnant patients. Our goal is to determine whether it could benefit the pregnant patient seeking smoking cessation. The aim of this investigation was to determine the role of human placenta in the disposition of bupropion and its major hepatic metabolite, OH-bupropion. The expression of efflux transporters P-gp and BCRP was determined in placental brush border membrane (n=200) and revealed a positive correlation (p<0.05). Bupropion was transported by BCRP (K(t) 3 microM, V(max) 30 pmol/mg protein/min) and P-gp (K(t) 0.5 microM, V(max) 6 pmol/mg protein min) in placental inside-out vesicles (IOVs). OH-bupropion crossed the dually-perfused human placental lobule without undergoing further metabolism, nor was it an efflux substrate of P-gp or BCRP. In conclusion, our data indicate that human placenta actively regulates the disposition of bupropion (via metabolism, active transport), but not its major hepatic metabolite, OH-bupropion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.