ArticleBiochimica et biophysica acta2010
Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).
Article in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Proton-Translocating NADH-Ubiquinone Oxidoreductase: Interaction with Artificial Electron Acceptors, Inhibitors, and Potential Medicines.International journal of molecular sciences · 2024Review
- Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I.Frontiers in chemistry · 2019Article
- Activation of respiratory Complex I fromHeliyon · 2017Article
- Redox-induced activation of the proton pump in the respiratory complex I.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- On the mechanism of respiratory complex I.Journal of bioenergetics and biomembranes · 2014Review
- Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli.The Journal of biological chemistry · 2013Article
- Stoichiometry of proton translocation by respiratory complex I and its mechanistic implications.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Tracing the trail of protons through complex I of the mitochondrial respiratory chain.PLoS biology · 2011Article
- A model of the proton translocation mechanism of complex I.The Journal of biological chemistry · 2011Article
- Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.PloS one · 2011Article
- Deep sequencing the transcriptome reveals seasonal adaptive mechanisms in a hibernating mammal.PloS one · 2011Article
- Transmembrane topology of subunit N of complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli.Journal of bioenergetics and biomembranes · 2010Article
- A new hypothesis on the simultaneous direct and indirect proton pump mechanisms in NADH-quinone oxidoreductase (complex I).FEBS letters · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In many energy transducing systems which couple electron and proton transport, for example, bacterial photosynthetic reaction center, cytochrome bc(1)-complex (complex III) and E. coli quinol oxidase (cytochrome bo(3) complex), two protein-associated quinone molecules are known to work together. T. Ohnishi and her collaborators reported that two distinct semiquinone species also play important roles in NADH-ubiquinone oxidoreductase (complex I). They were called SQ(Nf) (fast relaxing semiquinone) and SQ(Ns) (slow relaxing semiquinone). It was proposed that Q(Nf) serves as a "direct" proton carrier in the semiquinone-gated proton pump (Ohnishi and Salerno, FEBS Letters 579 (2005) 4555), while Q(Ns) works as a converter between one-electron and two-electron transport processes. This communication presents a revised hypothesis in which Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump. Q(Nf) and Q(Ns) together serve as (1e(-)/2e(-)) converter, for the transfer of reducing equivalent to the Q-pool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.