ReviewProgress in biophysics and molecular biology2011
Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling.
Review in Progress in biophysics and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Ratiometric Imaging for Quantification of Elevated CaACS chemical neuroscience · 2025Article
- Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Disrupted T-tubular network accounts for asynchronous calcium release in MTM1-deficient skeletal muscle.The Journal of physiology · 2023Article
- Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation.Genes · 2022Article
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
- Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research.Frontiers in physiology · 2022Review
- Article
- Comprehensive Simulation of CaInternational journal of molecular sciences · 2021Article
- Analyzing Developing Brain-On-Chip Cultures with the CALIMA Calcium Imaging Tool.Micromachines · 2021Article
- Article
- Sodium Transporters in Human Health and Disease.Frontiers in physiology · 2020Review
- Modeling and simulation of excitation- contraction coupling of fast-twitch skeletal muscle fibers.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Article
- A stochastic simulation of skeletal muscle calcium transients in a structurally realistic sarcomere model using MCell.PLoS computational biology · 2019Article
- Mechanical isolation, and measurement of force and myoplasmic free [CaNature protocols · 2017Article
- Doublet stimulation increases CaThe Journal of general physiology · 2017Article
- Modeling CaFrontiers in physiology · 2016Article
- Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca(2+) in Neurons and Astroglia.Neuron · 2015Article
- Imaging fast calcium currents beyond the limitations of electrode techniques.Biophysical journal · 2014Article
- Visualizing synaptic vesicle turnover and pool refilling driven by calcium nanodomains at presynaptic active zones of ribbon synapses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder.The Journal of general physiology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During excitation-contraction coupling in skeletal muscle, calcium ions are released into the myoplasm by the sarcoplasmic reticulum (SR) in response to depolarization of the fibre's exterior membranes. Ca(2+) then diffuses to the thin filaments, where Ca(2+) binds to the Ca(2+) regulatory sites on troponin to activate muscle contraction. Quantitative studies of these events in intact muscle preparations have relied heavily on Ca(2+)-indicator dyes to measure the change in the spatially-averaged myoplasmic free Ca(2+) concentration (Δ[Ca(2+)]) that results from the release of SR Ca(2+). In normal fibres stimulated by an action potential, Δ[Ca(2+)] is large and brief, requiring that an accurate measurement of Δ[Ca(2+)] be made with a low-affinity rapidly-responding indicator. Some low-affinity Ca(2+) indicators monitor Δ[Ca(2+)] much more accurately than others, however, as reviewed here in measurements in frog twitch fibres with sixteen low-affinity indicators. This article also examines measurements and simulations of Δ[Ca(2+)] in mouse fast-twitch fibres. The simulations use a multi-compartment model of the sarcomere that takes into account Ca(2+)'s release from the SR, its diffusion and binding within the myoplasm, and its re-sequestration by the SR Ca(2+) pump. The simulations are quantitatively consistent with the measurements and appear to provide a satisfactory picture of the underlying Ca(2+) movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.