Evidence map›Paper›PMID 20599398›Full record

Trial reportJournal of cardiothoracic and vascular anesthesia2010

Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery.

Frederic T Billings, Mias Pretorius, Edward D Siew, Chang Yu, Nancy J Brown

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiothoracic and vascular anesthesia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00141778 (RAAS, Inflammation, and Post-operative AF), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00141778 phase2 / phase3completednot on this map

RAAS, Inflammation, and Post-operative AF

TypeinterventionalSponsorVanderbilt UniversityRan2005 to 2010Enrolled455ConditionsAtrial FibrillationArmsPlacebo, Ramipril, Spironolactone
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Frederic T BillingsDepartment of Anesthesiology, Vanderbilt University, Nashville, TN, USA. frederic.t.billings@vanderbilt.edu
Mias Pretorius
Edward D Siew
Chang Yu
Nancy J Brown

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
GENES AND FIBRINOLYTIC CAPACITY OF HUMAN ENDOTHELIUMR01HL065193 · NHLBI · VANDERBILT UNIVERSITY · PI IKIZLER, TALAT ALP, PRETORIUS, MIAS · 2000 to 2012
$4.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2KL2RR024977 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$3.0M
RAAS, Inflammation &Post-Operative Atrial FibrillationR01HL077389 · NHLBI · VANDERBILT UNIVERSITY · PI BROWN, NANCY J. · 2005 to 2009
$2.7M
Bradykinin Receptor Antagonism During Cardiopulmonary BypassR01HL085740 · NHLBI · VANDERBILT UNIVERSITY · PI PRETORIUS, MIAS · 2006 to 2010
$2.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1TL1RR024978 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$1.3M
NCRR NIH HHS KL2 RR024977NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1RR024975NHLBI NIH HHS R01 HL065193NHLBI NIH HHS R01 HL077389NHLBI NIH HHS R01 HL085740NHLBI NIH HHS R01HL085740NHLBI NIH HHS R01HL65193NHLBI NIH HHS R01HL77389
6 · The paper itself

Abstract

objectiveTo test the hypothesis that perioperative statin use reduces acute kidney injury (AKI) after cardiac surgery.

designA retrospective analysis of prospectively collected data from an ongoing clinical trial.

settingA quaternary-care university hospital.

participantsThree hundred twenty-four adult elective cardiac surgery patients.

interventionsNone. MEASUREMENTS AND MAIN

resultsThe authors assessed the association of preoperative statin use, early postoperative statin use, and acute statin withdrawal with the incidence of AKI. Early postoperative statin use was defined as statin treatment within the first postoperative day. Statin withdrawal was defined as the discontinuation of preoperative statin treatment before surgery until at least postoperative day 2. Logistic regression and propensity score modeling were used to control for AKI risk factors. Sixty-eight of 324 patients (21.0%) developed AKI. AKI patients stayed in the hospital longer (p = 0.03) and were more likely to develop pneumonia (p = 0.002) or die (p = 0.001). A higher body mass index (p = 0.003), higher central venous pressure (p = 0.03), and statin withdrawal (27.4 v 14.7%, p = 0.046) were associated with a higher incidence of AKI, whereas early postoperative statin use was protective (12.5% v 23.8%, p = 0.03). Preoperative statin use did not affect the risk of AKI. In multivariate logistic regression, age (p = 0.03), male sex (p = 0.02), body mass index (p < 0.001), and early postoperative statin use (odds ratio = 0.32; 95% confidence interval, 0.14-0.72; p = 0.006) independently predicted AKI. Propensity score-adjusted risk assessment confirmed the association between early postoperative statin use and reduced AKI (odds ratio = 0.30; 95% confidence interval, 0.13-0.70; p = 0.005).

conclusionsEarly postoperative statin use is associated with a lower incidence of AKI among both chronic statin users and statin-naive cardiac surgery patients.

Indexed as

Acute Kidney InjuryAgedAnesthesiaAnticoagulantsAprotininAtrial FibrillationBody Mass IndexCardiac Surgical ProceduresCardiopulmonary BypassCritical CareFemaleHemostaticsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKidney Function TestsLogistic ModelsAnticoagulantsAprotininHemostaticsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID20599398
PMCPMC2992577

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.