ArticleJournal of neuroimmunology2010
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.
Article in Journal of neuroimmunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Cerebral amyloid angiopathy and the immune system.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Brain perivascular macrophages: current understanding and future prospects.Brain : a journal of neurology · 2024Review
- Brain macrophage development, diversity and dysregulation in health and disease.Cellular & molecular immunology · 2023Review
- Clodronate is not protective in lethal viral encephalitis despite substantially reducing inflammatory monocyte infiltration in the CNS.Frontiers in immunology · 2023Article
- Perivascular macrophages in the CNS: From health to neurovascular diseases.CNS neuroscience & therapeutics · 2022Review
- Meningeal macrophages protect against viral neuroinfection.Immunity · 2022Article
- Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages.Frontiers in molecular biosciences · 2022Article
- Brain perivascular macrophages: Recent advances and implications in health and diseases.CNS neuroscience & therapeutics · 2019Review
- Macrophages at CNS interfaces: ontogeny and function in health and disease.Nature reviews. Neuroscience · 2019Review
- Perivascular macrophages in health and disease.Nature reviews. Immunology · 2018Review
- CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage.Acta neuropathologica communications · 2018Article
- Controllable and uncontrollable stress differentially impact pathogenicity and survival in a mouse model of viral encephalitis.Journal of neuroimmunology · 2018Article
- Genetic Models of Macrophage Depletion.Methods in molecular biology (Clifton, N.J.) · 2018Review
- Activating Peripheral Innate Immunity Enables Safe and Effective Oncolytic Virotherapy in the Brain.Molecular therapy oncolytics · 2017Article
- Brain perivascular macrophages: characterization and functional roles in health and disease.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model.Neoplasia (New York, N.Y.) · 2015Article
- Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis.Journal of neuroimmunology · 2014Article
- PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases.The American journal of pathology · 2014Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.