ArticleThe American journal of cardiology2010
Impact of baseline systolic blood pressure on long-term outcomes in patients with advanced chronic systolic heart failure (insights from the BEST trial).
Article in The American journal of cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Factors associated with hospitalisations of patients with chronic heart failure approaching the end of life: A systematic review.Palliative medicine · 2022Pooled it
- Pharmacological interventions for heart failure in people with chronic kidney disease.The Cochrane database of systematic reviews · 2020Pooled it
- The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy--5-year follow-up.Lipids in health and disease · 2013Trial
- Bucindolol, systolic blood pressure, and outcomes in systolic heart failure: a prespecified post hoc analysis of BEST.The Canadian journal of cardiology · 2012Trial
- Effect of warfarin on outcomes in septuagenarian patients with atrial fibrillation.The American journal of cardiology · 2012Trial
- Predictors of heart failure readmission and all-cause mortality in patients with acute heart failure.International journal of cardiology · 2024Observational
- Blood pressure and heart failure: focused on treatment.Clinical hypertension · 2024Review
- Longitudinal machine learning model for predicting systolic blood pressure in patients with heart failure.Journal of preventive medicine and hygiene · 2023Article
- Predictors and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With a Left Ventricular Ejection Fraction Above or Below 60.Journal of the American Heart Association · 2022Article
- Prognostic impact of systolic blood pressure in acute heart failure with preserved ejection fraction in older patients.ESC heart failure · 2021Observational
- The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry. Rationale, design and objectives.Journal of human hypertension · 2021Article
- Systolic Blood Pressure and Outcomes in Older Patients with HFpEF and Hypertension.The American journal of medicine · 2021Article
- Introduction of sacubitril/valsartan in primary care follow-up of heart failure: a prospective observational study (THESEUS).ESC heart failure · 2020Observational
- Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.Journal of the American College of Cardiology · 2019Article
- One- to 10-Day Versus 11- to 30-Day All-Cause Readmission and Mortality in Older Patients With Heart Failure.The American journal of cardiology · 2019Article
- Towards tailoring blood pressure control in HFpEF: Lessons from OPTIMIZE-HF.Global cardiology science & practice · 2019Article
- Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.JAMA cardiology · 2018Observational
- Emphasis on abdominal obesity as a modifier of eplerenone effect in heart failure: hypothesis-generating signals from EMPHASIS-HF.European journal of heart failure · 2017Article
- Calcium channel blockers and outcomes in older patients with heart failure and preserved ejection fraction.Circulation. Heart failure · 2014Article
- Recommendations to prescribe in complex older adults: results of the CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) project.Drugs & aging · 2014Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
The impact of baseline systolic blood pressure (SBP) on outcomes in patients with advanced chronic systolic heart failure (HF) has not been studied using a propensity-matched design. Of the 2,706 participants in the Beta-Blocker Evaluation of Survival Trial (BEST) with chronic HF, New York Heart Association class III to IV symptoms and left ventricular ejection fraction < or =35%, 1,751 had SBP < or =120 mm Hg (median 108, range 70 to 120) and 955 had SBP >120 mm Hg (median 134, range 121 to 192). Propensity scores for SBP >120 mm Hg, calculated for each patient, were used to assemble a matched cohort of 545 pairs of patients with SBPs < or =120 and >120 mm Hg who were balanced in 65 baseline characteristics. Matched Cox regression models were used to estimate associations between SBP < or =120 mm Hg and outcomes over 4 years of follow-up. Matched participants had a mean age +/- SD of 62 +/- 12 years, 24% were women, and 24% were African-American. HF hospitalization occurred in 38% and 32% of patients with SBPs < or =120 and >120 mm Hg, respectively (hazard ratio 1.33 SBP < or =120 was compared to >120 mm Hg, 95% confidence interval 1.04 to 1.69, p = 0.023). All-cause mortality occurred in 28% and 30% of matched patients with SBPs < or =120 and >120 mm Hg, respectively (hazard ratio 1.13 SBP < or =120 compared to >120 mm Hg, 95% confidence interval 0.86 to 1.49, p = 0.369). In conclusion, in patients with advanced chronic systolic HF, baseline SBP < or =120 mm Hg is associated with increased risk of HF hospitalization, but had no association with all-cause mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.