ReviewTrends in endocrinology and metabolism: TEM2010
A FoxL in the Smad house: activin regulation of FSH.
Review in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Discovery proteomics identification of factors contributing to gonadotropin β expression.Endocrinology · 2026Article
- Evidence for FOXL2 Association with the Tsc1 Regulatory Region in Mice.Biomolecules · 2026Article
- Relationship between Pituitary Gland and Stem Cell in the Aspect of Hormone Production and Disease Prevention: A Narrative Review.Endocrine, metabolic & immune disorders drug targets · 2025Review
- FOXO1 mitigates the SMAD3/FOXL2Journal of translational medicine · 2021Article
- Signaling pathways and promoter regions that mediate pituitary adenylate cyclase activating polypeptide (PACAP) self-regulation in gonadotrophs.Molecular and cellular endocrinology · 2020Article
- SMAD-FOXL2 Regulation of FSHB: A Game of Human and Mouse.Endocrinology · 2020Article
- Gain-of-Function Genetic Models to Study FSH Action.Frontiers in endocrinology · 2019Review
- Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD.Stem cell research & therapy · 2018Article
- Regulation of reproduction via tight control of gonadotropin hormone levels.Molecular and cellular endocrinology · 2018Review
- Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines.Reproductive biology and endocrinology : RB&E · 2017Article
- Foxo1 Is Required for Normal Somatotrope Differentiation.Endocrinology · 2016Article
- Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.The Journal of biological chemistry · 2015Article
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- Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice.Endocrinology · 2014Article
- Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.Molecular and cellular endocrinology · 2014Review
- Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.PloS one · 2014Article
- Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.Molecular endocrinology (Baltimore, Md.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Follicle-stimulating hormone (FSH), produced by pituitary gonadotrope cells, is required for maturation of ovarian follicles. The FSHbeta subunit is the limiting factor for production of mature hormone and provides biological specificity. Activin dramatically induces FSHbeta transcription and the secondary rise in FSH, important for follicular development, is dependent on this induction. Thus, regulation of FSHbeta levels by activin is crucial for female reproductive fitness. This review discusses activin signaling pathways, transcription factors and FSHbeta promoter elements required for activin responsiveness. Because FoxL2, a forkhead transcription factor, was recently shown to be instrumental in relaying activin signaling to the FSHbeta promoter, we focus in this paper on its role and the inter-relatedness of several key players in activin responsiveness on the FSHbeta promoter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.