ArticleFEBS letters2010
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.
Article in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Loss of Wave1 gene defines a subtype of lethal prostate cancer.Oncotarget · 2015Pooled it
- Adaptor protein Abelson interactor 1 in homeostasis and disease.Cell communication and signaling : CCS · 2024Review
- Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling.Molecular oncology · 2023Article
- Roles for 3' Phosphoinositides in Macropinocytosis.Sub-cellular biochemistry · 2022Article
- Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition.Cell communication and signaling : CCS · 2021Review
- PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.The Journal of cell biology · 2020Article
- CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Journal of hematology & oncology · 2020Article
- Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.Cell communication and signaling : CCS · 2019Article
- Bone marrow-specific loss ofBlood · 2018Article
- Macropinocytosis, mTORC1 and cellular growth control.Cellular and molecular life sciences : CMLS · 2018Review
- The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.Cell communication and signaling : CCS · 2015Article
- Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia.Leukemia · 2014Article
- Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells.Molecular cancer · 2014Article
- RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.Journal of cell science · 2012Article
- Endocytic pathways involved in filovirus entry: advances, implications and future directions.Viruses · 2012Review
- Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.Oncogenesis · 2012Article
- Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.FEBS letters · 2012Review
- The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.Molecular and cellular biology · 2012Article
- Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling.Genes & cancer · 2012Article
- Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Genes & cancer · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Macropinocytosis is regulated by Abl kinase via an unknown mechanism. We previously demonstrated that Abl kinase activity is, itself, regulated by Abi1 subsequent to Abl kinase phosphorylation of Abi1 tyrosine 213 (pY213) [1]. Here we show that blocking phosphorylation of Y213 abrogated the ability of Abl to regulate macropinocytosis, implicating Abi1 pY213 as a key regulator of macropinocytosis. Results from screening the human SH2 domain library and mapping the interaction site between Abi1 and the p85 regulatory domain of PI-3 kinase, coupled with data from cells transfected with loss-of-function p85 mutants, support the hypothesis that macropinocytosis is regulated by interactions between Abi1 pY213 and the C-terminal SH2 domain of p85-thereby linking Abl kinase signaling to p85-dependent regulation of macropinocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.