Trial reportNutrition journal2010
Daily egg consumption in hyperlipidemic adults--effects on endothelial function and cardiovascular risk.
Trial report in Nutrition journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Pooled it
- Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis.The American journal of clinical nutrition · 2013Pooled it
- Consumption of Eggs Alone or Enriched with Annatto (Nutrients · 2023Trial
- Lactic-fermented egg white improves visceral fat obesity in Japanese subjects-double-blind, placebo-controlled study.Lipids in health and disease · 2017Trial
- Lactic-fermented egg white reduced serum cholesterol concentrations in mildly hypercholesterolemic Japanese men: a double-blind, parallel-arm design.Lipids in health and disease · 2017Trial
- One-year daily consumption of buttermilk drink containing lutein-enriched egg-yolks does not affect endothelial function in fasting and postprandial state.Scientific reports · 2017Trial
- Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial.Journal of the American College of Nutrition · 2012Trial
- Frequency of Egg Intake Associated with Mortality in Chinese Adults: An 8-Year Nationwide Cohort Study.International journal of environmental research and public health · 2022Article
- Egg consumption and risk of acute stroke in the Million Veteran Program.Clinical nutrition ESPEN · 2022Article
- RNA Sequencing Reveals Key Metabolic Pathways Are Modified by Short-Term Whole Egg Consumption.Frontiers in nutrition · 2021Article
- Egg consumption and risk of coronary artery disease in the Million Veteran Program.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Development of omega-3 rich eggs through dietary flaxseed and bio-evaluation in metabolic syndrome.Food science & nutrition · 2020Article
- Egg consumption, cardiovascular diseases and type 2 diabetes.European journal of clinical nutrition · 2018Review
- Dietary cholesterol and egg yolk should be avoided by patients at risk of vascular disease.Journal of translational internal medicine · 2016Review
- The Fifty Year Rehabilitation of the Egg.Nutrients · 2015Review
- Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System: A Report From the Workshop Convened by the World Heart Federation.Journal of the American College of Cardiology · 2015Review
- Egg Consumption and Human Cardio-Metabolic Health in People with and without Diabetes.Nutrients · 2015Review
- Review
- Dietary Cholesterol and Plasma Lipoprotein Profiles: Randomized-Controlled Trials.Current nutrition reports · 2013Article
- Effect of daily egg ingestion with thai food on serum lipids in hyperlipidemic adults.ISRN nutrition · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLimiting consumption of eggs, which are high in cholesterol, is generally recommended to reduce risk of cardiovascular disease. However, recent evidence suggests that dietary cholesterol has limited influence on serum cholesterol or cardiac risk.
objectiveTo assess the effects of egg consumption on endothelial function and serum lipids in hyperlipidemic adults.
methodsRandomized, placebo-controlled crossover trial of 40 hyperlipidemic adults (24 women, 16 men; average age = 59.9 +/- 9.6 years; weight = 76.3 +/- 21.8 kilograms; total cholesterol = 244 +/- 24 mg/dL). In the acute phase, participants were randomly assigned to one of the two sequences of a single dose of three medium hardboiled eggs and a sausage/cheese breakfast sandwich. In the sustained phase, participants were then randomly assigned to one of the two sequences of two medium hardboiled eggs and 1/2 cup of egg substitute daily for six weeks. Each treatment assignment was separated by a four-week washout period. Outcome measures of interest were endothelial function measured as flow mediated dilatation (FMD) and lipid panel.
resultsSingle dose egg consumption had no effects on endothelial function as compared to sausage/cheese (0.4 +/- 1.9 vs. 0.4 +/- 2.4%; p = 0.99). Daily consumption of egg substitute for 6 weeks significantly improved endothelial function as compared to egg (1.0 +/- 1.2% vs. -0.1 +/- 1.5%; p < 0.01) and lowered serum total cholesterol (-18 +/- 18 vs. -5 +/- 21 mg/dL; p < 0.01) and LDL (-14 +/- 20 vs. -2 +/- 19 mg/dL; p = 0.01). Study results (positive or negative) are expressed in terms of change relative to baseline.
conclusionsEgg consumption was found to be non-detrimental to endothelial function and serum lipids in hyperlipidemic adults, while egg substitute consumption was beneficial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.