ArticleACS nano2010
Computational microscopy of the role of protonable surface residues in nanoprecipitation oscillations.
Article in ACS nano, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Controlling Ion Dynamics at Nanoscale for Memristor-Based Neuromorphic Computing.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Structure and response to flow of the glycocalyx layer.Biophysical journal · 2014Article
- Dynamic control of nanoprecipitation in a nanopipette.ACS nano · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A novel phenomenon has recently been reported in polymeric nanopores. This phenomenon, so-called nanoprecipitation, is characterized by the transient formation of precipitates in the nanopore lumen, producing a sequence of low and high conductance states in the ionic current through the pore. By means of all-atom molecular dynamics simulations, we studied nanoprecipitation for polyethylene terephthalate nanopore immersed in electrolytic solution containing calcium phosphate, covering a total simulation time of 1.24 micros. Our results suggest that protonable surface residues at the nanopore surface, namely carboxyl groups, trigger the formation of precipitates that strongly adhere to the surface, blocking the pore and producing the low conductance state. On the basis of the simulations, we propose a mechanism for the formation of the high conductance state; the mechanism involves detachment of the precipitate from the surface due to reprotonation of carboxyl groups and subsequent translocation of the precipitate out of the pore.
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