ArticleJournal of the American Chemical Society2010
Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins.Scientific reports · 2021Article
- Functionalized Particles Designed for Targeted Delivery.Polymers · 2021Review
- Quantum Dot Labeling and Visualization of Extracellular Vesicles.ACS applied nano materials · 2020Article
- Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.Angewandte Chemie (International ed. in English) · 2017Review
- Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2017Article
- 3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase.ACS nano · 2016Article
- The surface science of nanocrystals.Nature materials · 2016Review
- Reversible Control of Nanoparticle Functionalization and Physicochemical Properties by Dynamic Covalent Exchange.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2015Article
- Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange.Angewandte Chemie (International ed. in English) · 2015Article
- Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials.ACS nano · 2013Article
- Thiol antioxidant-functionalized CdSe/ZnS quantum dots: synthesis, characterization, cytotoxicity.Journal of biomedical nanotechnology · 2013Article
- Fine tuning of spatial arrangement of enzymes in a PCNA-mediated multienzyme complex using a rigid poly-L-proline linker.PloS one · 2013Article
- Aromatic aldehyde and hydrazine activated peptide coated quantum dots for easy bioconjugation and live cell imaging.Bioconjugate chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Water solubilized nanoparticles such as CdSe-ZnS core-shell nanocrystals (quantum dots, QDs) have great potential in bioimaging and sensing applications due to their excellent photophysical properties. However, the efficient modification of QDs with complex biomolecules represents a significant challenge. Here, we describe a straightforward arylhydrazone approach for the chemoselective covalent modification of QDs that is compatible with neutral pH and micromolar concentrations of the peptide target. The kinetics of covalent modification can be monitored spectroscopically at 354 nm in the presence of the QD and average peptide/QD ratios from 2:1 to 11:1 were achieved with excellent control over the desired valency. These results suggest that aniline catalyzed hydrazone ligation has the potential to provide a general method for the controlled assembly of a variety of nanoparticle-biomolecule hybrids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.