ArticleOrganic letters2010
Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.
Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Molecular engineering of Cyanine-Hoechst hybrid materials for nanoscale DNA and chromatin imaging.JPhys materials · 2026Article
- Luminescence Properties of Hoechst 33258 in Polyvinyl Alcohol Films.International journal of molecular sciences · 2025Article
- HI-NESS: a family of genetically encoded DNA labels based on a bacterial nucleoid-associated protein.Nucleic acids research · 2022Article
- SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein.Molecular imaging and biology · 2019Article
- Updated developments on molecular imaging and therapeutic strategies directed against necrosis.Acta pharmaceutica Sinica. B · 2019Article
- Rhodamine-Hoechst positional isomers for highly efficient staining of heterochromatin.Chemical science · 2019Article
- Evaluation of Necrosis Avidity and Potential for Rapid Imaging of Necrotic Myocardium of Radioiodinated Hypocrellins.Molecular imaging and biology · 2018Article
- Article
- Evaluation of Radioiodinated 1,4-Naphthoquinones as Necrosis Avid Agents for Rapid Myocardium Necrosis Imaging.Molecular imaging and biology · 2018Article
- Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents.Contrast media & molecular imaging · 2018Article
- NovelACS medicinal chemistry letters · 2017Article
- Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium.Scientific reports · 2016Article
- Developing injectable nanomaterials to repair the heart.Current opinion in biotechnology · 2015Review
- An authentic imaging probe to track cell fate from beginning to end.Nature communications · 2014Article
- Targeting extracellular DNA to deliver IGF-1 to the injured heart.Scientific reports · 2014Article
- H-gemcitabine: a new gemcitabine prodrug for treating cancer.Bioconjugate chemistry · 2013Article
- Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications.Journal of Cancer · 2013Article
- Biomarkers and molecular probes for cell death imaging and targeted therapeutics.Bioconjugate chemistry · 2012Review
- Oxidative condensations to form benzimidazole-substituted potassium organotrifluoroborates.Organic letters · 2012Article
- Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models.Theranostics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/d-galactosamine (LPS-GalN) induced sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.