ArticleAge (Dordrecht, Netherlands)2011
Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals.
Article in Age (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- PIEZO1-mediated mechanosensation links aging to bladder dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium pathways.Scientific reports · 2023Article
- Purinergic signalling in the urinary bladder - When function becomes dysfunction.Autonomic neuroscience : basic & clinical · 2021Article
- Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone.Scientific reports · 2019Article
- The aging bladder insights from animal models.Asian journal of urology · 2018Review
- Age-related changes in function and gene expression of the male and female mouse bladder.Scientific reports · 2018Article
- Octodon degus, a new model to study the agonist and plexus-induced response in the urinary bladder.Journal of physiology and biochemistry · 2017Article
- Translational Research and Functional Changes in Voiding Function in Older Adults.Clinics in geriatric medicine · 2015Review
- Aging changes agonist induced contractile responses in permeabilized rat bladder.Age (Dordrecht, Netherlands) · 2015Article
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Neurogenic mechanisms in bladder and bowel ageing.Biogerontology · 2015Review
- Contemporary concepts in the aetiopathogenesis of detrusor underactivity.Nature reviews. Urology · 2014Review
- Pathophysiology and animal modeling of underactive bladder.International urology and nephrology · 2014Review
- Association of inflammaging (inflammation + aging) with higher prevalence of OAB in elderly population.International urology and nephrology · 2014Article
- Purinergic signalling in the urinary tract in health and disease.Purinergic signalling · 2014Review
- Age-related changes in afferent pathways and urothelial function in the male mouse bladder.The Journal of physiology · 2014Article
- Article
- Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle.Age (Dordrecht, Netherlands) · 2012Article
- Pathogenesis evidence from human and animal models of detrusor underactivity.Tzu chi medical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although aging-induced changes in urinary bladder neurotransmission have been studied in some detail, information regarding alterations in detrusor muscle is scanty and addresses only partial aspects of the myogenic response of detrusor. Rodent bladder aging shows several features similar to those reported in humans. The aim of this study was to characterize in aged mouse the alterations of detrusor muscle contraction and the putative underlying changes in Ca(2+) signals. We studied in vitro the myogenic contraction induced by agonists in detrusor strips from adult (3 months old) or aged (23-25 months old) mice. In addition, we determined the agonist-induced [Ca(2+)](i) signals by epifluorescence microscopy in fura-2 loaded isolated detrusor cells. Aging impaired the contractile response of bladder strips to cholinergic stimulation with bethanechol and to chemical depolarization with KCl-containing solutions. On the contrary, the response to purinergic stimulation (ATP) was enhanced. Aging also diminished the transient Ca(2+) signal evoked by bethanechol and the Ca(2+) influx induced by KCl in bladder strips. Treatments aimed to release calcium from intracellular stores (caffeine and a low level of ionomycin in Ca(2+)-free medium) showed that aging reduces the size of agonist-releasable stores. Similar to contraction, the mobilization of Ca(2+) by ATP was increased in aged cells. Therefore, the differential effects of aging on detrusor contraction are associated to alterations of [Ca(2+)](i) signals: the cholinergic inhibition is due to inhibition of voltage-operated Ca(2+) influx and reduction of the size of intracellular Ca(2+) stores, while the age-induced ATP response is accompanied by an enhanced Ca(2+) mobilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.