ArticlePloS one2010
Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review.Biological psychiatry · 2016Pooled it
- Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation.Clinical epigenetics · 2018Article
- Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals.Translational psychiatry · 2017Article
- CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?Current psychiatry reports · 2016Review
- The landscape of DNA methylation amid a perfect storm of autism aetiologies.Nature reviews. Neuroscience · 2016Review
- DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas.Acta neuropathologica communications · 2016Article
- Investigating epigenetic consequences of early-life adversity: some methodological considerations.European journal of psychotraumatology · 2016Article
- Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- Article
- Epigenetic Alterations in Alzheimer's Disease.Frontiers in behavioral neuroscience · 2015Review
- The molecular bases of the suicidal brain.Nature reviews. Neuroscience · 2014Review
- The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Current behavioral neuroscience reports · 2014Article
- Cellular commitment in the developing cerebellum.Frontiers in cellular neuroscience · 2014Review
- Genome-wide methylation analyses in glioblastoma multiforme.PloS one · 2014Article
- DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.Brain : a journal of neurology · 2013Article
- A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology.Molecular psychiatry · 2013Review
- DNA methylation signatures in development and aging of the human prefrontal cortex.American journal of human genetics · 2012Article
- Article
- Genetic contributions to intergroup responses: a cautionary perspective.Frontiers in human neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEmerging evidence suggests that DNA methylation plays an expansive role in the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of DNA methylation in brain development and function. METHODOLOGY/SIGNIFICANT
findingsUsing methylation-sensitive SNP chip analysis (MSNP), we performed whole genome DNA methylation profiling of the prefrontal, occipital, and temporal regions of cerebral cortex, as well as cerebellum. These data provide an unbiased representation of CpG sites comprising 377,509 CpG dinucleotides within both the genic and intergenic euchromatic region of the genome. Our large-scale genome DNA methylation profiling reveals that the prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal, occipital, and temporal cortices are significantly more methylated as compared to the cerebellum.
conclusionsThese findings are consistent with known developmental differences in nucleosome repeat lengths in cerebral and cerebellar cortices, with cerebrum exhibiting shorter repeat lengths than cerebellum. Our observed differences in DNA methylation profiles in these regions underscores the potential role of DNA methylation in chromatin structure and organization in CNS, reflecting functional specialization within cortical regions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.