ArticleHippokratia2010
The role of endothelium and endogenous vasoactive substances in sepsis.
Article in Hippokratia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Paediatrics: how to manage septic shock.Drugs in context · 2021Review
- Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis.Clinical science (London, England : 1979) · 2018Review
- The effects of microRNA-34a regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide-induced human umbilical vein endothelial cells.World journal of emergency medicine · 2017Article
- Formyl Peptide Receptor Activation Elicits Endothelial Cell Contraction and Vascular Leakage.Frontiers in immunology · 2016Article
- Functional differences between the arteries perfusing gas exchange and nutritional membranes in the late chicken embryo.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Protective effect of Xin Mai Jia ultrafiltration extract on human umbilical vein endothelial cell injury induced by hydrogen peroxide and the effect on the NO-cGMP signaling pathway.Experimental and therapeutic medicine · 2014Article
- Mitochondrial-derived N-formyl peptides: novel links between trauma, vascular collapse and sepsis.Medical hypotheses · 2013Article
- Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients - study protocol.World journal of emergency surgery : WJES · 2013Article
- Adrenomedullin: possible predictor of insulin resistance in women with polycystic ovary syndrome.Journal of endocrinological investigation · 2012Article
- Vasogenic shock physiology.Open access emergency medicine : OAEM · 2011Review
- Central mediators involved in the febrile response: effects of antipyretic drugs.Temperature (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis and septic shock are great challenges for the doctors who treat critically ill patients. A big part of the scientific community is performing researches about the pathophysiology and treatment of this clinical problem. The endothelium has a very significant role in the alterations that sepsis causes especially to the circulatory system. The disorders of the normal function of the endothelium include derangement of the vascular tone, increase of endothelium permeability, activation of the endothelial cells, production of various regulators and disorders of coagulation. Nitric oxide is the modulator that mediates the action of most vasodilators. The overproduction of nitric oxide during sepsis is possibly the most important cause of the vasopressor-resistant hypotension which characterizes septic shock. The levels of natriuretic peptides are also increased. These peptides act through several ways on the circulatory system both peripherally and directly on the myocardium. Endothelin, vasopressin, adrenomedullin and prostacyclin are vasoactive substances that have their own role in the regulation of the circulatory system during sepsis.
Indexed as
Identifiers
20596262PMC2895286W2312134624What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.