Evidence map›Paper›PMID 20595679›Full record

ArticleJournal of the American Society of Nephrology : JASN2010

HLA has strongest association with IgA nephropathy in genome-wide analysis.

John Feehally, Martin Farrall, Anne Boland, Daniel P Gale, Ivo Gut, Simon Heath, Ashish Kumar, John F Peden, Patrick H Maxwell, David L Morris and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 7 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 7 syntheses or guidelines pooled it, 276 citations in OpenAlex.

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  9. A Rare Genetic Defect ofFrontiers in immunology · 2019
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

John FeehallyThe John Walls Renal Unit, Leicester General Hospital and Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom. jf27@le.ac.uk
Martin Farrall
Anne Boland
Daniel P Gale
Ivo Gut
Simon Heath
Ashish Kumar
John F Peden
Patrick H Maxwell
David L Morris
Sandosh Padmanabhan
Timothy J Vyse
Anna Zawadzka
Andrew J Rees
Mark Lathrop
Peter J Ratcliffe
University of Oxford · GBUCL Australia · AUMedical University of Vienna · ATUniversity of Glasgow · GBUniversity of Leicester · GB

Funding

Medical Research Council G0600420Wellcome TrustWellcome Trust 075491/Z/04
6 · The paper itself

Abstract

Demographic and family studies support the existence of a genetic contribution to the pathogenesis of IgA nephropathy, but results from genetic association studies of candidate genes are inconsistent. To systematically survey common genetic variation in this disease, we performed a genome-wide analysis in a cohort of patients with IgA nephropathy selected from the UK Glomerulonephritis DNA Bank. We used two groups of controls: parents of affected individuals and previously genotyped, unaffected, ancestry-matched individuals from the 1958 British Birth Cohort and the UK Blood Service. We genotyped 914 affected or family controls for 318,127 single nucleotide polymorphisms (SNPs). Filtering for low genotype call rates and inferred non-European ancestry left 533 genotyped individuals (187 affected children) for the family-based association analysis and 244 cases and 4980 controls for the case-control analysis. A total of 286,200 SNPs with call rates >95% were available for analysis. Genome-wide analysis showed a strong signal of association on chromosome 6p in the region of the MHC (P = 1 × 10(-9)). The two most strongly associated SNPs showed consistent association in both family-based and case-control analyses. HLA imputation analysis showed that the strongest association signal arose from a combination of DQ loci with some support for an independent HLA-B signal. These results suggest that the HLA region contains the strongest common susceptibility alleles that predispose to IgA nephropathy in the European population.

Indexed as

Genome-Wide Association StudyCase-Control StudiesChromosomes, Human, Pair 6FemaleGenome, HumanGlomerulonephritis, IGAHLA AntigensHumansMajor Histocompatibility ComplexMalePolymorphism, Single NucleotideUnited KingdomHLA Antigens

Identifiers

PMID20595679
PMCPMC3013538
OpenAlexW2127788608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.