ArticleThe American journal of pathology2010
Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Opioid abuse and SIV infection in non-human primates.Journal of neurovirology · 2023Review
- Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy.Viruses · 2022Article
- Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS.PloS one · 2018Article
- Modeling brain lentiviral infections during antiretroviral therapy in AIDS.Journal of neurovirology · 2017Article
- A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.PLoS pathogens · 2017Article
- Humanized mouse models for HIV-1 infection of the CNS.Journal of neurovirology · 2015Review
- Spatiotemporal dynamics of simian immunodeficiency virus brain infection in CD8+ lymphocyte-depleted rhesus macaques with neuroAIDS.The Journal of general virology · 2014Article
- Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.Journal of virology · 2014Article
- Animal models of HIV peripheral neuropathy.Future virology · 2014Article
- Giant cell encephalitis and microglial infection with mucosally transmitted simian-human immunodeficiency virus SHIVSF162P3N in rhesus macaques.Journal of neurovirology · 2014Article
- Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs.PloS one · 2012Article
- Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques.Journal of neurovirology · 2011Article
- Pathogenesis of HIV in the central nervous system.Current HIV/AIDS reports · 2011Review
- Simian immunodeficiency virus macaque models of HIV latency.Current opinion in HIV and AIDS · 2011Review
- A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system.Current opinion in HIV and AIDS · 2011Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Antiretroviral drugs suppress virus burden in the cerebrospinal fluid of HIV-infected individuals; however, the direct effect of antiretrovirals on virus replication in brain parenchyma is poorly understood. We investigated the effect of short-term combined antiretroviral therapy (CART) on brain virus burden in rhesus monkeys using the CD8-depletion model of accelerated simian immunodeficiency virus (SIV) encephalitis. Four monkeys received CART (consisting of the nonpenetrating agents PMPA and RCV) for four weeks, beginning 28 days after SIV inoculation. Lower virus burdens were measured by real-time RT-PCR in four of four regions of brain from monkeys that received CART as compared with four SIV-infected, untreated controls; however, the difference was only significant for the frontal cortex (P < 0.05). In contrast, significantly lower virus burdens were measured in plasma and four of five lymphoid compartments from animals that received CART. Surprisingly, despite normalization of neuronal function in treated animals, the numbers of activated macrophages/microglia and the magnitude of TNF-alpha mRNA expression in brain were similar between treated animals and controls. These results suggest that short-term therapy with antiretrovirals that fail to penetrate the blood-cerebrospinal fluid barrier can reduce brain virus burden provided systemic virus burden is suppressed; however, longer treatment may be required to completely resolve encephalitic lesions and microglial activation, which may reflect the longer half-life of the principal target cells of HIV/SIV in the brain (macrophages) versus lymphoid tissues (T lymphocytes).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.