ArticleAJNR. American journal of neuroradiology2010
Assessment of craniospinal pressure-volume indices.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects.Magnetic resonance in medicine · 2026Article
- Arterial-related craniospinal physiological compliance assessed by phase-contrast MRI and lumbar infusion test.Brain communications · 2026Article
- Pediatric low-pressure hydrocephalus: a case series and re-analysis of a rare disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Assessing cerebral microvascular volumetric with high-resolution 4D cerebral blood volume MRI at 7 T.Nature cardiovascular research · 2025Article
- B-waves in noninvasive capacitance signal correlate with B-waves in ICP.Acta neurochirurgica · 2025Article
- Cerebral pulsatility might be a driver of neurofunctional reorganization in the aging brain: an MRI and NIRS study.Frontiers in aging neuroscience · 2025Article
- Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries.Fluids and barriers of the CNS · 2024Article
- Assessing Cerebral Microvascular Volumetric Pulsatility with High-Resolution 4D CBV MRI at 7T.medRxiv : the preprint server for health sciences · 2024Article
- Embracing uncertainty in cerebrospinal fluid dynamics: A Bayesian approach to analysing infusion studies.Brain & spine · 2024Article
- Changes of cerebrospinal fluid pressure gradient in different body positions under experimental impairment of cerebrospinal fluid pathway: new insight into hydrocephalus development.Frontiers in molecular neuroscience · 2024Article
- Human intracranial pulsatility during the cardiac cycle: a computational modelling framework.Fluids and barriers of the CNS · 2022Article
- Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics.Fluids and barriers of the CNS · 2022Article
- Spinal Compliance Curves: Preliminary Experience with a New Tool for Evaluating Suspected CSF Venous Fistulas on CT Myelography in Patients with Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2021Article
- Hemodynamic Patterns of Spinal Cord Perfusion in Thoracoabdominal Aortic Aneurysm Repair.Aorta (Stamford, Conn.) · 2021Article
- Does the brain have mechanical compliance?Magma (New York, N.Y.) · 2020Article
- Multiparametric flow analysis using four-dimensional flow magnetic resonance imaging can detect cerebral hemodynamic impairment in patients with internal carotid artery stenosis.Neuroradiology · 2020Article
- Comparing invasive with MRI-derived intracranial pressure measurements in healthy elderly and brain trauma cases: A pilot study.Journal of magnetic resonance imaging : JMRI · 2019Observational
- Enhanced in vitro model of the CSF dynamics.Fluids and barriers of the CNS · 2019Article
- Patient-specific cranio-spinal compliance distribution using lumped-parameter model: its relation with ICP over a wide age range.Fluids and barriers of the CNS · 2018Article
- ICP curve morphology and intracranial flow-volume changes: a simultaneous ICP and cine phase contrast MRI study in humans.Acta neurochirurgica · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe PVI(CC) of the craniospinal compartment defines the shape of the pressure-volume curve and determines the damping of cyclic arterial pulsations. Despite no reports of direct measurements of the PVI(CC) among healthy elderly, it is believed that a change away from adequate accommodation of cardiac-related pulsations may be a pathophysiologic mechanism seen in neurodegenerative disorders such as Alzheimer disease and idiopathic normal pressure hydrocephalus. In this study, blood and CSF flow measurements are combined with lumbar CSF infusion measurements to assess the craniospinal PVI(CC) and its distribution of cranial and spinal compartments in healthy elderly. MATERIALS AND
methodsThirty-seven healthy elderly were included (60-82 years of age). The cyclic arterial volume change and the resulting shift of CSF to the spinal compartment were quantified by PC-MR imaging. In addition, each subject underwent a lumbar CSF infusion test in which the magnitude of cardiac-related pulsations in intracranial pressure was quantified. Finally, the PVI was calculated by using a mathematic model.
resultsAfter excluding 2 extreme values, the craniospinal PVI(CC) was calculated to a mean of 9.8 ± 2.7 mL and the estimated average 95% confidence interval of individual measurements was ± 9%. The average intracranial and spinal contributions to the overall compliance were 65% and 35% respectively (n = 35).
conclusionsCombining lumbar CSF infusion and PC-MR imaging proved feasible and robust for assessment of the craniospinal PVI(CC). This study produced normative values and showed that the major compensatory contribution was located intracranially.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.