ArticleJournal of the American Medical Informatics Association : JAMIA
Analyzing categorical information in two publicly available drug terminologies: RxNorm and NDF-RT.
Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Medication-indication knowledge bases: a systematic review and critical appraisal.Journal of the American Medical Informatics Association : JAMIA · 2015Pooled it
- Long-Term Opioid Therapy Among Patients With Systemic Lupus Erythematosus in the Community: A Lupus Midwest Network (LUMEN) Study.The Journal of rheumatology · 2023Article
- Alignment of vaccine codes using an ontology of vaccine descriptions.Journal of biomedical semantics · 2022Article
- Comparing the variability of ingredient, strength, and dose form information from electronic prescriptions with RxNorm drug product descriptions.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol).International journal of epidemiology · 2020Article
- Review
- Development of an algorithm to link electronic health record prescriptions with pharmacy dispense claims.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Quantifying the impact of chronic conditions on a diagnosis of major depressive disorder in adults: a cohort study using linked electronic medical records.BMC psychiatry · 2016Article
- HITSZ_CDR: an end-to-end chemical and disease relation extraction system for BioCreative V.Database : the journal of biological databases and curation · 2016Article
- Incidence and Risk Factors for Progression From Short-term to Episodic or Long-term Opioid Prescribing: A Population-Based Study.Mayo Clinic proceedings · 2015Article
- Are All Vaccines Created Equal? Using Electronic Health Records to Discover Vaccines Associated With Clinician-Coded Adverse Events.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015Article
- Evaluation of RxNorm for Medication Clinical Decision Support.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014Article
- Standardizing adverse drug event reporting data.Journal of biomedical semantics · 2014Article
- Age and sex patterns of drug prescribing in a defined American population.Mayo Clinic proceedings · 2013Article
- Extracting drug indication information from structured product labels using natural language processing.Journal of the American Medical Informatics Association : JAMIA · 2013Article
- Lessons learned from developing a drug evidence base to support pharmacovigilance.Applied clinical informatics · 2013Article
- Cross-terminology mapping challenges: a demonstration using medication terminological systems.Journal of biomedical informatics · 2012Article
- Clinical research informatics: a conceptual perspective.Journal of the American Medical Informatics Association : JAMIA · 2012Article
- Integrating VA's NDF-RT drug terminology with PharmGKB: preliminary results.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2012Article
- Further revamping VA's NDF-RT drug terminology for clinical research.Journal of the American Medical Informatics Association : JAMIA · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe RxNorm and NDF-RT (National Drug File Reference Terminology) are a suite of terminology standards for clinical drugs designated for use in the US federal government systems for electronic exchange of clinical health information. Analyzing how different drug products described in these terminologies are categorized into drug classes will help in their better organization and classification of pharmaceutical information.
methodsMappings between drug products in RxNorm and NDF-RT drug classes were extracted. Mappings were also extracted between drug products in RxNorm to five high-level NDF-RT categories: Chemical Structure; cellular or subcellular Mechanism of Action; organ-level or system-level Physiologic Effect; Therapeutic Intent; and Pharmacokinetics. Coverage for the mappings and the gaps were evaluated and analyzed algorithmically.
resultsApproximately 54% of RxNorm drug products (Semantic Clinical Drugs) were found not to have a correspondence in NDF-RT. Similarly, approximately 45% of drug products in NDF-RT are missing from RxNorm, most of which can be attributed to differences in dosage, strength, and route form. Approximately 81% of Chemical Structure classes, 42% of Mechanism of Action classes, 75% of Physiologic Effect classes, 76% of Therapeutic Intent classes, and 88% of Pharmacokinetics classes were also found not to have any RxNorm drug products classified under them. Finally, various issues regarding inconsistent mappings between drug concepts were identified in both terminologies.
conclusionThis investigation identified potential limitations of the existing classification systems and various issues in specification of correspondences between the concepts in RxNorm and NDF-RT. These proposals and methods provide the preliminary steps in addressing some of the requirements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.