ArticleJournal of experimental botany2010
Auxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells.
Article in Journal of experimental botany, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- KNUCKLES regulates floral meristem termination by controlling auxin distribution and cytokinin activity.The Plant cell · 2024Article
- 3,4-Dichlorophenylacetic acid acts as an auxin analog and induces beneficial effects in various crops.Communications biology · 2024Article
- New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.Life (Basel, Switzerland) · 2022Review
- Fluorescent biosensors illuminating plant hormone research.Plant physiology · 2021Review
- Indole-3-Acetic Acid Is Synthesized by the EndophyteInternational journal of molecular sciences · 2021Article
- A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis.Scientific reports · 2019Article
- Lateral root initiation and formation within the parental root meristem of Cucurbita pepo: is auxin a key player?Annals of botany · 2018Article
- Advances in Understanding the Mechanism of Action of the Auxin Permease AUX1.International journal of molecular sciences · 2018Review
- Enhanced Conjugation of Auxin by GH3 Enzymes Leads to Poor Adventitious Rooting in Carnation Stem Cuttings.Frontiers in plant science · 2018Article
- RopGEF1 Plays a Critical Role in Polar Auxin Transport in Early Development.Plant physiology · 2017Article
- Review
- Inhibitors of plant hormone transport.Protoplasma · 2016Review
- Auxin-driven patterning with unidirectional fluxes.Journal of experimental botany · 2015Article
- Current insights into hormonal regulation of microspore embryogenesis.Frontiers in plant science · 2015Review
- Single-cell-based system to monitor carrier driven cellular auxin homeostasis.BMC plant biology · 2013Article
- Auxin transport at cellular level: new insights supported by mathematical modelling.Journal of experimental botany · 2012Article
- Polar auxin transport: an early invention.Journal of experimental botany · 2012Article
- AUX/LAX family of auxin influx carriers-an overview.Frontiers in plant science · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytohormone auxin is transported through the plant body either via vascular pathways or from cell to cell by specialized polar transport machinery. This machinery consists of a balanced system of passive diffusion combined with the activities of auxin influx and efflux carriers. Synthetic auxins that differ in the mechanisms of their transport across the plasma membrane together with polar auxin transport inhibitors have been used in many studies on particular auxin carriers and their role in plant development. However, the exact mechanism of action of auxin efflux and influx inhibitors has not been fully elucidated. In this report, the mechanism of action of the auxin influx inhibitors (1-naphthoxyacetic acid (1-NOA), 2-naphthoxyacetic acid (2-NOA), and 3-chloro-4-hydroxyphenylacetic acid (CHPAA)) is examined by direct measurements of auxin accumulation, cellular phenotypic analysis, as well as by localization studies of Arabidopsis thaliana L. auxin carriers heterologously expressed in Nicotiana tabacum L., cv. Bright Yellow cell suspensions. The mode of action of 1-NOA, 2-NOA, and CHPAA has been shown to be linked with the dynamics of the plasma membrane. The most potent inhibitor, 1-NOA, blocked the activities of both auxin influx and efflux carriers, whereas 2-NOA and CHPAA at the same concentration preferentially inhibited auxin influx. The results suggest that these, previously unknown, activities of putative auxin influx inhibitors regulate overall auxin transport across the plasma membrane depending on the dynamics of particular membrane vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.