ArticleChemical senses2010
Evidence for an integrated oral sensory module in the human anterior ventral insula.
Article in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hunger and BMI modulate neural responses to sweet stimuli: fMRI meta-analysis.International journal of obesity (2005) · 2020Pooled it
- Trial
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- Oral thermal processing in the gustatory cortex of awake mice.Chemical senses · 2023Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- Reframing appetitive reinforcement learning and reward valuation as effects mediated by hippocampal-dependent behavioral inhibition.Nutrition research (New York, N.Y.) · 2020Review
- Anatomical stability of human fungiform papillae and relationship with oral perception measured by salivary response and intensity rating.Scientific reports · 2019Article
- fMRI-Based Brain Responses to Quinine and Sucrose Gustatory Stimulation for Nutrition Research in the Minipig Model: A Proof-of-Concept Study.Frontiers in behavioral neuroscience · 2018Article
- Family history of alcoholism and the human brain response to oral sucrose.NeuroImage. Clinical · 2018Article
- Thermal taster status: Evidence of cross-modal integration.Human brain mapping · 2016Article
- Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
- Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism.Physiology & behavior · 2015Review
- The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors.Progress in neurobiology · 2015Review
- The Brain Mechanisms Underlying the Perception of Pungent Taste of Capsaicin and the Subsequent Autonomic Responses.Frontiers in human neuroscience · 2015Article
- Differential psychophysiological interactions of insular subdivisions during varied oropharyngeal swallowing tasks.Physiological reports · 2014Article
- Ventromedial prefrontal cortex response to concentrated sucrose reflects liking rather than sweet quality coding.Chemical senses · 2013Article
- Localization of the primary taste cortex by contrasting passive and attentive conditions.Experimental brain research · 2013Article
- Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.Behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Taste, which is almost always accompanied by other oral sensations, serves to identify potential nutrients and toxins. The present study was designed to determine the influence of sensory modality (chemesthetic vs. gustatory) and physiological significance (potentially nutritive vs. potentially harmful) on insular response to oral stimulation. Sixteen subjects underwent functional magnetic resonance imaging scanning while receiving 2 potentially nutritive solutions (sucrose and NaCl), 2 potentially harmful solutions (quinine and capsaicin, a chemesthetic stimulus), and a tasteless control solution. We identified a region of anterior ventral insula that responded to oral stimulation irrespective of modality or physiological significance. However, when subjects tasted a potentially nutritive stimulus, the connectivity between the insula and a feeding network including the hypothalamus, ventral pallidum, and striatum was greater than when tasting a potentially harmful stimulus. No differential connectivity was observed as a function of modality (gustatory vs. chemesthetic). These results support the existence of an integrated supramodal flavor system in the anterior ventral insula that preferentially communicates with the circuits guiding feeding when the flavor is potentially nutritive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.