ArticleBMC pediatrics2010
Molecular identification of adenovirus causing respiratory tract infection in pediatric patients at the University of Malaya Medical Center.
Article in BMC pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- High-incidence of human adenoviral co-infections in taiwan.PloS one · 2013Trial
- Genomic Characterization of Human Adenovirus Type 21 Strains - 7 PLADs, China, 2023-2024.China CDC weekly · 2025Article
- Risk factors of severe conditions in hospitalized children with adenovirus infection and chest CT features.BMC pediatrics · 2024Article
- Molecular epidemiology of human adenoviruses in children with and without respiratory symptoms: Preliminary findings from a case-control study.BMC pediatrics · 2022Article
- Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China.Influenza and other respiratory viruses · 2021Article
- An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55.BMC infectious diseases · 2020Article
- Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan, China.Journal of medical virology · 2019Article
- Article
- Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus.Virology journal · 2018Article
- The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly.Biomedicines · 2018Review
- Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia.PloS one · 2018Article
- Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection.Canadian respiratory journal · 2018Article
- Respiratory viruses in patients with influenza-like illness in Senegal: Focus on human respiratory adenoviruses.PloS one · 2017Article
- Molecular epidemiology of a post-influenza pandemic outbreak of acute respiratory infections in Korea caused by human adenovirus type 3.Journal of medical virology · 2015Article
- Article
- Molecular identification of adenoviruses associated with respiratory infection in Egypt from 2003 to 2010.BMC infectious diseases · 2014Article
- Molecular characterization of human adenovirus infection in Thailand, 2009-2012.Virology journal · 2013Article
- Detection of three human adenovirus species in adults with acute respiratory infection in China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Human adenovirus type 7 outbreak in Police Training Center, Malaysia, 2011.Emerging infectious diseases · 2012Article
- A molecular epidemiology survey of respiratory adenoviruses circulating in children residing in Southern Palestine.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are at least 51 adenovirus serotypes (AdV) known to cause human infections. The prevalence of the different human AdV (HAdV) serotypes varies among different regions. Presently, there are no reports of the prevalent HAdV types found in Malaysia. The present study was undertaken to identify the HAdV types associated primarily with respiratory tract infections (RTI) of young children in Malaysia.
methodsArchived HAdV isolates from pediatric patients with RTI seen at the University of Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia from 1999 to 2005 were used. Virus isolates were inoculated into cell culture and DNA was extracted when cells showed significant cytopathic effects. AdV partial hexon gene was amplified and the sequences together with other known HAdV hexon gene sequences were used to build phylogenetic trees. Identification of HAdV types found among young children in Malaysia was inferred from the phylograms.
resultsAt least 2,583 pediatric patients with RTI sought consultation and treatment at the UMMC from 1999 to 2005. Among these patients, 48 (< 2%) were positive for HAdV infections. Twenty-seven isolates were recovered and used for the present study. Nineteen of the 27 (approximately 70%) isolates belonged to HAdV species C (HAdV-C) and six (approximately 22%) were of HAdV species B (HAdV-B). Among the HAdV-C species, 14 (approximately 74%) of them were identified as HAdV type 1 (HAdV-1) and HAdV type 2 (HAdV-2), and among the HAdV-B species, HAdV type 3 (HAdV-3) was the most common serotype identified. HAdV-C species also was isolated from throat and rectal swabs of children with hand, foot, and mouth disease (HFMD). Two isolates were identified as corresponding to HAdV-F species from a child with HFMD and a patient with intestinal obstruction.
conclusionsHAdV-1 and HAdV-2 were the most common HAdV isolated from pediatric patients who sought treatment for RTI at the UMMC from 1999 to 2005. HAdV-B, mainly HAdV-3, was recovered from approximately 22% of the patients. These findings provide a benchmark for future studies on the prevalence and epidemiology of HAdV types in Malaysia and in the region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.