ArticleTheoretical biology & medical modelling2010
A statistical model for mapping morphological shape.
Article in Theoretical biology & medical modelling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Statistical Shape Modeling of the Clavicle: Morphological Variation, Sex Differences, and Surgical Implications.Orthopaedic surgery · 2026Article
- Genetic Architecture of Heterophylly: Single and Multi-Leaf Genome-Wide Association Mapping inFrontiers in plant science · 2022Article
- Multi-dimensional machine learning approaches for fruit shape phenotyping in strawberry.GigaScience · 2020Article
- Statistical shape models of cuboid, navicular and talus bones.Journal of foot and ankle research · 2017Article
- A graphical weighted power improving multiplicity correction approach for SNP selections.Current genomics · 2014Article
- Holm multiple correction for large-scale gene-shape association mapping.BMC genetics · 2014Article
- Theoretical Biology and Medical Modelling: ensuring continued growth and future leadership.Theoretical biology & medical modelling · 2013Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundLiving things come in all shapes and sizes, from bacteria, plants, and animals to humans. Knowledge about the genetic mechanisms for biological shape has far-reaching implications for a range spectrum of scientific disciplines including anthropology, agriculture, developmental biology, evolution and biomedicine.
resultsWe derived a statistical model for mapping specific genes or quantitative trait loci (QTLs) that control morphological shape. The model was formulated within the mixture framework, in which different types of shape are thought to result from genotypic discrepancies at a QTL. The EM algorithm was implemented to estimate QTL genotype-specific shapes based on a shape correspondence analysis. Computer simulation was used to investigate the statistical property of the model.
conclusionBy identifying specific QTLs for morphological shape, the model developed will help to ask, disseminate and address many major integrative biological and genetic questions and challenges in the genetic control of biological shape and function.
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Registered trials
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