ArticleExpert review of clinical immunology2010
Crohn's disease as an immunodeficiency.
Article in Expert review of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Trial
- Novel Microbial-Based Immunotherapy Approach for Crohn's Disease.Frontiers in medicine · 2019Article
- Systems Pharmacological Approach ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging.PLoS pathogens · 2016Article
- Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn's Disease.Nutrients · 2015Article
- Site-Specific Immunomodulator: A Novel Treatment for Crohn's Disease.Gastroenterology research and practice · 2015Article
- Principal component analysis characterizes shared pathogenetics from genome-wide association studies.PLoS computational biology · 2014Article
- Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease.BMC immunology · 2014Article
- What is wrong with granulocytes in inflammatory bowel diseases?Digestive diseases (Basel, Switzerland) · 2013Review
- A Potential 'Curative' Modality for Crohn's Disease---Modeled after Prophylaxis of Bovine Johne's Disease.Mycobacterial diseases : tuberculosis & leprosy · 2012Article
- New frontiers in primary immunodeficiency disorders: immunology and beyond….Cellular and molecular life sciences : CMLS · 2012Review
- Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's disease?European journal of microbiology & immunology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The pathogenesis of Crohn's disease (CD) has widely been regarded as the consequence of a dysregulated T-cell-mediated response to intestinal microbes, and the majority of the worldwide research effort has focused on characterizing and treating the chronic inflammatory phase of the disease. However, recent molecular biological and clinical investigations indicate that CD is actually a primary immunodeficiency. At first counter-intuitive, the apparent paradox of a pathogenic innate immune defect can be linked mechanistically to the granulomatous chronic inflammation characteristic of the disease. Genome-wide association studies have corroborated the involvement of innate immune dysfunction in the pathogenesis of CD, but less than 20% of the heritable risk is accounted for. By contrast, in vitro and in vivo stimulation of the immune system has highlighted novel areas of interest that may lead to the development of targeted therapeutic and diagnostic tools.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.