Evidence map›Paper›PMID 20594129›Full record

ArticleExpert review of clinical immunology2010

Mucosal T cells in gut homeostasis and inflammation.

Femke van Wijk, Hilde Cheroutre

Open access · greenAbstract read
In one paragraph

Article in Expert review of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 109 citations in OpenAlex.

  1. Use of Antihistamine Drugs in Colitis: A Review.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. The role of integrins in T cell-mediated resistance tobioRxiv : the preprint server for biology · 2026
    Article
  4. Gut-brain axis in health and brain disease.Chinese medical journal · 2026
    Review
  5. Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Femke van WijkDivision of Developmental Immunology, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Hilde Cheroutre
La Jolla Institute for Immunology · US

Funding

Mucosal immune regulation by CD8aa+ cellsR01AI050265 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CHEROUTRE, HILDE MC · 2001 to 2015
$5.5M
Selective Instructions for Memory T CellsR01AI064584 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CHEROUTRE, HILDE MC · 2005 to 2015
$4.5M
Regulation and mechanism of agonist selectionR01DK054451 · NIDDK · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CHEROUTRE, HILDE MC · 2004 to 2008
$2.1M
NIAID NIH HHS R01 AI050265NIAID NIH HHS R01AI050265NIAID NIH HHS R01 AI064584NIDDK NIH HHS R01 DK054451
6 · The paper itself

Abstract

The antigen-rich environment of the gut interacts with a highly integrated and specialized mucosal immune system that has the challenging task of preventing invasion and the systemic spread of microbes, while avoiding excessive or unnecessary immune responses to innocuous antigens. Disruption of the mucosal barrier and/or defects in gut immune regulatory networks may lead to chronic intestinal inflammation as seen in inflammatory bowel disease. The T-cell populations of the intestine play a critical role in controlling intestinal homeostasis, and their unique phenotypes and diversities reflect the sophisticated mechanisms that have evolved to maintain the delicate balance between immune activation and tolerance at mucosal sites. In this article, we will discuss the specialized properties of mucosal T cells in the context of immune homeostasis and inflammation.

Indexed as

Gastrointestinal TractHomeostasisHumansImmunity, MucosalInflammationIntestinal MucosaModels, ImmunologicalT-Lymphocytes

Identifiers

PMID20594129
PMCPMC2976609
OpenAlexW2109021251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.