ArticleInternational urology and nephrology2011
Renal reserve in the oldest old.
Article in International urology and nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03629561 (Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Low-energy cooling strategies modulate biomarkers of kidney injury risk in older adults exposed to very hot and dry heat.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Gastro-Intestinal Tolerance and Renal Safety of Protein Oral Nutritional Supplements in Nursing Home Residents: A Randomized Controlled Trial.The journal of nutrition, health & aging · 2016Trial
- Association of Preoperative Serum Magnesium Levels and Acute Kidney Injury Following Thromboembolectomy in Acute Limb Ischemia.The Eurasian journal of medicine · 2026Article
- A Comprehensive Framework for Kidney Function Assessment: Summary of the National Institute of Diabetes and Digestive and Kidney Diseases Reimagining Kidney Function Assessment Workshop.Kidney international reports · 2025Article
- Causes, Complications and Short-Term Outcome of Acute Kidney Injury in a Resource-Limited Setting.International journal of nephrology · 2024Article
- Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.BMC nephrology · 2019Observational
- A prospective study of clinical characteristics and outcomes of acute kidney injury in a tertiary care Centre.BMC nephrology · 2019Article
- How do lupus glomerulonephritis and its treatment affect the renal reserve?International urology and nephrology · 2019Article
- New Insights into Chronological Mobility of Retrotransposons In Vivo.Oxidative medicine and cellular longevity · 2019Article
- The aging kidney and the nephrotoxic effects of mercury.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Syndrome of rapid onset end stage renal disease in incident Mayo Clinic chronic hemodialysis patient.Indian journal of nephrology · 2014Article
- Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old.World journal of nephrology · 2012Article
- Renal creatinine handling in very old patients with chronic renal disease.International urology and nephrology · 2011Article
- Renal reserve in the oldest old: calculation of concerns regarding creatinine clearance rate with cimetidine in the elderly.International urology and nephrology · 2011Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDecline in glomerular filtration rate (GFR) is one of several changes in renal physiology in the elderly. Renal reserve (RR) is the kidney's capacity to increase its basal GFR by at least 20% after a protein overload. Even though it has already been reported that RR is preserved in healthy old people, there is no information whether RR is also preserved in the healthy very old one (older than 74 of age), which we decided to study and report our findings in this paper. MATERIAL AND
methodWe studied RR in 16 healthy persons divided into three age groups: young: 20-40 years old (n: 5): 64-74 years old (n: 6) and oldest old: >74 years old (n: 5). Renal reserve test was performed by assessing creatinine clearance with cimetidine before and after an oral protein load. Statistical analysis was performed using ANOVA test.
resultsEven though renal reserve response was present in all age groups, its magnitude (delta GFR) was significantly higher in the healthy young group (103.6 ± 53 ml/min) compared to the old one (34.1 ± 40 ml/min) (P = 0.002), while it was significantly lower in the healthy oldest old (20.7 ± 0.7 ml/min) group compared to the other two groups (P = 0.002).
conclusionRenal reserve is preserved in healthy very old people, but its magnitude decreases significantly with age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.