Evidence map›Paper›PMID 20593303›Full record

ReviewPharmaceutical research2010

Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis.

Hu Yang

Abstract readReview
In one paragraph

Review in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 204 citations in OpenAlex.

  1. Diabetic neuropathy: cutting-edge research and future directions.Signal transduction and targeted therapy · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hu YangDepartment of Biomedical Engineering School of Engineering, Virginia Commonwealth University, 401 West Main Street, P.O. Box 843067, Richmond, Virginia 23284, USA. hyang2@vcu.edu
Virginia Commonwealth University · US

Funding

Brain-targeted nanomedicine via buccal administrationR21NS063200 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI YANG, HU · 2009 to 2010
$395k
NINDS NIH HHS R21 NS063200
6 · The paper itself

Abstract

Central nervous system (CNS) diseases represent the largest and fastest-growing area of unmet medical need. Nanotechnology plays a unique instrumental role in the revolutionary development of brain-specific drug delivery, imaging, and diagnosis. With the aid of nanoparticles of high specificity and multifunctionality, such as dendrimers and quantum dots, therapeutics, imaging agents, and diagnostic molecules can be delivered to the brain across the blood-brain barrier (BBB), enabling considerable progress in the understanding, diagnosis, and treatment of CNS diseases. Nanoparticles used in the CNS for drug delivery, imaging, and diagnosis are reviewed, as well as their administration routes, toxicity, and routes to cross the BBB. Future directions and major challenges are outlined.

Indexed as

Central Nervous System DiseasesMagnetic Resonance ImagingNanoparticlesAnimalsBlood-Aqueous BarrierDendrimersDrug CarriersEndothelial CellsFerric CompoundsHumansLiposomesPharmaceutical PreparationsQuantum DotsTranscytosisDendrimersDrug CarriersFerric Compoundsferric oxideLiposomesPAMAM StarburstPharmaceutical Preparations

Identifiers

PMID20593303
PMCPMC2933363
OpenAlexW2153200726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.