ArticleNeurocritical care2010
Loss of cortisol circadian rhythm in patients with traumatic brain injury: a microdialysis evaluation.
Article in Neurocritical care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Extracranial Effects of Traumatic Brain Injury: A Narrative Review.Clinics and practice · 2025Review
- The Surgical Stress Response and Anesthesia: A Narrative Review.Journal of clinical medicine · 2024Review
- Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury.Frontiers in cellular neuroscience · 2024Review
- Acute neuroendocrine changes after traumatic brain injury.Brain & spine · 2024Review
- Article
- Sleep Disorders Following Mild and Moderate Traumatic Brain Injury.Brain sciences · 2019Article
- Circadian variations in melatonin and cortisol in patients with cervical spinal cord injury.Spinal cord · 2016Article
- Traumatic brain injury-induced sleep disorders.Neuropsychiatric disease and treatment · 2016Review
- Hypopituitarism in Traumatic Brain Injury-A Critical Note.Journal of clinical medicine · 2015Article
- Recovery of stress response coincides with responsiveness to voluntary exercise after traumatic brain injury.Journal of neurotrauma · 2014Article
- Does the neuroprotective role of anandamide display diurnal variations?International journal of molecular sciences · 2013Article
- Temperature and heart rate responses to exercise following mild traumatic brain injury.Journal of neurotrauma · 2013Article
- Neuroendocrine changes in patients with spontaneous supratentorial intracerebral hemorrhage.Neurocritical care · 2013Article
- Traumatic brain injury and sleep disorders.Neurologic clinics · 2012Review
- Article
- Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury.Journal of neurotrauma · 2011Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraumatic brain injury (TBI) is commonly associated with disturbances of the hypothalamic-pituitary-adrenal axis secretion. Cerebral microdialysis techniques have been recently applied to measure brain interstitial cortisol levels.
methodsWe evaluated for the first time the circadian rhythm of cortisol secretion at 08:00, 16:00, and 24:00 h in the acute phase of TBI by determination of total serum and brain interstitial cortisol levels (microdialysis samples) in 10 patients with TBI. Non-parametric Friedman's two way analysis of variance test was used.
resultsMean age was 29.8 ± 13.6 years. Median Glasgow Coma Scale score after resuscitation was 5 (range 3-10). No differences were found in total serum (P = 0.26) and brain interstitial cortisol (P = 0.77) in the whole sample. Intraindividual analysis showed that circadian variability was lost in all patients, both in serum and brain interstitial cortisol samples in the acute phase after TBI.
conclusionIn our series, circadian variability of cortisol evaluated by serum and cerebral microdialysis samples seems to be lost in TBI patients.
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