Evidence map›Paper›PMID 20592864›Full record

ReviewOrganogenesis

Regulation of cellular chromatin state: insights from quiescence and differentiation.

Surabhi Srivastava, Rakesh K Mishra, Jyotsna Dhawan

Abstract readReview
In one paragraph

Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Prime Editing in Dividing and Quiescent Cells.International journal of molecular sciences · 2025
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  9. Epigenetic Control of Osteogenic Lineage Commitment.Frontiers in cell and developmental biology · 2020
    Review
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  18. Control of vertebrate development by MYC.Cold Spring Harbor perspectives in medicine · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Surabhi SrivastavaCentre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India. ssurabhi@ccmb.res.in
Rakesh K Mishra
Jyotsna Dhawan

Funding

Wellcome Trust
6 · The paper itself

Abstract

The identity and functionality of eukaryotic cells is defined not just by their genomic sequence which remains constant between cell types, but by their gene expression profiles governed by epigenetic mechanisms. Epigenetic controls maintain and change the chromatin state throughout development, as exemplified by the setting up of cellular memory for the regulation and maintenance of homeotic genes in proliferating progenitors during embryonic development. Higher order chromatin structure in reversibly arrested adult stem cells also involves epigenetic regulation and in this review we highlight common trends governing chromatin states, focusing on quiescence and differentiation during myogenesis. Together, these diverse developmental modules reveal the dynamic nature of chromatin regulation providing fresh insights into the role of epigenetic mechanisms in potentiating development and differentiation.

Indexed as

Gene Expression Regulation, DevelopmentalAdult Stem CellsAnimalsBody PatterningCell DifferentiationCell Growth ProcessesChromatinEpigenesis, GeneticHumansMuscle DevelopmentResting Phase, Cell CycleChromatinchromatin statehoxmyogenesispolycombquiescenceregenerationsatellite cellstrithorax

Identifiers

PMID20592864
PMCPMC2861742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.