Evidence map›Paper›PMID 20592759›Full record

ArticleDermatology research and practice2010

Desmosomes in developing human epidermis.

Sirkku Peltonen, Laura Raiko, Juha Peltonen

Abstract read
In one paragraph

Article in Dermatology research and practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sirkku PeltonenDepartment of Dermatology, University of Turku and Turku University Hospital, PL 52, 20521 Turku, Finland.
Laura Raiko
Juha Peltonen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are rare due to the difficult accessibility to the samples. Although the morphology of periderm cells and the process how the epidermis develops very much resemble each other, the timetable and the final outcome of a mature human epidermis markedly differ from those of murine skin. Even the genetic basis of the junctional components may have profound differences between the species, which might affect the implementation of the data from animal models in human studies. The aim of this review is to focus on the development of human skin with special emphasis on desmosomes. Desmosomal development is mirrored in perspective with other simultaneous events, such as maturation of adherens, tight and gap junctions, and the basement membrane zone.

Identifiers

PMID20592759
PMCPMC2879547

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.