ArticleInternational journal of pediatrics2010
Influence of zinc supplementation in acute diarrhea differs by the isolated organism.
Article in International journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Oral zinc for treating diarrhoea in children.The Cochrane database of systematic reviews · 2016Pooled it
- Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.Nutrients · 2013Pooled it
- What zinc supplementation does and does not achieve in diarrhea prevention: a systematic review and meta-analysis.BMC infectious diseases · 2011Pooled it
- Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial.The New England journal of medicine · 2020Trial
- Article
- Zinc for Acute Diarrhea and Amoxicillin for Pneumonia, Do They Work? : Delivered at the AIIMS, IJP Excellence Award for the year 2013 on 7th September 2014.Indian journal of pediatrics · 2015Article
- Review
- Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop.The American journal of clinical nutrition · 2014Article
- Zinc protects against Shiga-toxigenic Escherichia coli by acting on host tissues as well as on bacteria.BMC microbiology · 2014Article
- From ambivalent to divalent: Has the "zinc age" finally arrived?Virulence · 2013Article
- Roles of zinc in the pathophysiology of acute diarrhea.Current infectious disease reports · 2012Article
- Zinc in acute childhood diarrhea: Is it universally effective?Indian journal of pharmacology · 2012Article
- Serum zinc levels of hospitalized children with acute diarrhea differ by the isolated viruses.International journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc supplementation is recommended in all acute diarrheas in children from developing countries. We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas. We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation. Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism-beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. Although we found similar results for the outcome of high stool volume, the results did not reach statistical significance. Our findings suggest that the current strategy of zinc supplementation in all cases of acute diarrheas in children may need appropriate fine tuning to optimize the therapeutic benefit based on the causative organism, but further studies need to confirm and extend our findings.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.