ArticleScience translational medicine2010
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.
Article in Science translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.Molecular oncology · 2013Trial
- A new gene expression signature, the ClinicoMolecular Triad Classification, may improve prediction and prognostication of breast cancer at the time of diagnosis.Breast cancer research : BCR · 2011Trial
- Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.Nature genetics · 2024Article
- Pan-cancer mutational signature surveys correlated mutational signature with geospatial environmental exposures and viral infections.Computational and structural biotechnology journal · 2023Article
- Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.Cancer cell · 2022Article
- Genetic alterations associated with multiple primary malignancies.Cancer medicine · 2021Article
- Mammary epithelial cells have lineage-rooted metabolic identities.Nature metabolism · 2021Article
- Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes.Cancers · 2021Article
- Article
- Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer.Frontiers in genetics · 2020Article
- Article
- Recent Advances in the Treatment of Breast Cancer.Frontiers in oncology · 2018Review
- Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nature communications · 2017Article
- Article
- Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.Breast cancer research : BCR · 2017Article
- Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response.Breast cancer (Dove Medical Press) · 2017Article
- Article
- Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- A semiparametric Bayesian model for comparing DNA copy numbers.Brazilian journal of probability and statistics · 2016Article
- Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors.
Funding
Abstract
Distinct molecular subtypes of breast carcinomas have been identified, but translation into clinical use has been limited. We have developed two platform-independent algorithms to explore genomic architectural distortion using array comparative genomic hybridization data to measure (i) whole-arm gains and losses [whole-arm aberration index (WAAI)] and (ii) complex rearrangements [complex arm aberration index (CAAI)]. By applying CAAI and WAAI to data from 595 breast cancer patients, we were able to separate the cases into eight subgroups with different distributions of genomic distortion. Within each subgroup data from expression analyses, sequencing and ploidy indicated that progression occurs along separate paths into more complex genotypes. Histological grade had prognostic impact only in the luminal-related groups, whereas the complexity identified by CAAI had an overall independent prognostic power. This study emphasizes the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that objective score of genomic complexity (CAAI) is an independent prognostic marker in breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.