ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Protective Effect Against Acute Experimental Toxoplasmosis Conferred by Intranasal Immunisation withVaccines · 2026Article
- MicroRNA-155 contributes to host immunity against Toxoplasma gondii.Parasite (Paris, France) · 2021Article
- Neurological and Neurobehavioral Disorders Associated withJournal of parasitology research · 2021Review
- Investigating immune responses to parasites using transgenesis.Parasites & vectors · 2019Review
- A latent ability to persist: differentiation in Toxoplasma gondii.Cellular and molecular life sciences : CMLS · 2018Review
- P2X7 receptor-dependent tuning of gut epithelial responses to infection.Immunology and cell biology · 2017Article
- STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.mBio · 2016Article
- Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.Scientific reports · 2015Article
- Role of CD4+ Foxp3+ Regulatory T Cells in Protection Induced by a Live Attenuated, Replicating Type I Vaccine Strain of Toxoplasma gondii.Infection and immunity · 2015Article
- Possible link between Toxoplasma gondii and the anosmia associated with neurodegenerative diseases.American journal of Alzheimer's disease and other dementias · 2014Review
- Biomarker analysis revealed distinct profiles of innate and adaptive immunity in infants with ocular lesions of congenital toxoplasmosis.Mediators of inflammation · 2014Article
- Toxoplasmosis.Handbook of clinical neurology · 2013Article
- Use and abuse of dendritic cells by Toxoplasma gondii.Virulence · 2012Review
- Immune response and immunopathology during toxoplasmosis.Seminars in immunopathology · 2012Review
- IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite.Microbes and infection · 2012Article
- Modulation of innate immunity by Toxoplasma gondii virulence effectors.Nature reviews. Microbiology · 2012Review
- Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Nucleic acid transfection and transgenesis in parasitic nematodes.Parasitology · 2012Review
- Toxoplasma gondii effectors are master regulators of the inflammatory response.Trends in parasitology · 2011Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The Toxoplasma gondii population consists of multiple strains, defined by genotype and virulence. Previous studies have established that protective immunity to this organism is mediated by IL-12, which drives T cells to produce IFN-gamma. Paradoxically, although type I and type II strains of T. gondii both induce IL-12 and IFN-gamma in the mouse, type I parasites are lethal, whereas type II strains establish chronic infection. The cellular basis for these strain-dependent differences remains unclear. To better understand these events, the CD8(+) T cell and dendritic cell (DC) responses to transgenic, OVA-expressing type I RH (RH OVA) and type II Prugniuad (Pru OVA) parasites were examined. Pru OVA-infected mice developed a robust DC response at the site of infection and the draining lymph node and generated a population of endogenous OVA-specific CD8(+) T cells. In contrast, RH OVA-infected mice had fewer DCs and OVA-specific CD8(+) T cells. RH OVA-infected mice given preactivated OVA-specific CD8(+) T cells were protected, suggesting that reduced DC-derived signals contributed to the low OVA-specific CD8(+) T cell numbers observed during type I infection. Indeed, DC depletion prior to Pru OVA infection resulted in a failure to generate activated OVA-specific CD8(+) T cells, and IL-12p70 treatment during RH OVA infection modestly increased the number of Ag-specific cells. Together, these data are consistent with a model of immunity to T. gondii in which strain-dependent DC responses shape the generation of Ag-specific CD8(+) T cells and determine the outcome of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.