ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Synaptic scaling and the development of a motor network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Differential modification of perceptual thresholds by prolonged near threshold motion in healthy adults and after peripheral lesions.Frontiers in neurology · 2025Article
- Homeostatic Regulation of Motoneuron Properties in Development.Advances in neurobiology · 2022Review
- Mechanisms underlying homeostatic plasticity in theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development.The Journal of comparative neurology · 2017Article
- β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity.Acta neuropathologica communications · 2016Article
- Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A hybrid electrical/chemical circuit in the spinal cord generates a transient embryonic motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Homeostatic synaptic plasticity in developing spinal networks driven by excitatory GABAergic currents.Neuropharmacology · 2014Review
- Comparison and contrast of noise-induced hyperactivity in the dorsal cochlear nucleus and inferior colliculus.Hearing research · 2013Article
- Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function.Cold Spring Harbor perspectives in biology · 2012Review
- Manipulations of spinal cord excitability evoke developmentally-dependent compensatory changes in the lamprey spinal cord.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neurons respond homeostatically to chronic changes in network activity with compensatory changes such as a uniform alteration in the size of miniature postsynaptic current (mPSC) amplitudes termed synaptic scaling. However, little is known about the impact of synaptic scaling on the function of neural networks in vivo. We used the embryonic zebrafish to address the effect of synaptic scaling on the neural network underlying locomotion. Activity was decreased during development by TTX injection to block action potentials or CNQX injection to block glutamatergic transmission. Alternatively TNFalpha was chronically applied. Recordings from spinal neurons showed that glutamatergic mPSCs scaled up approximately 25% after activity reduction and fortuitously scaled down approximately 20% after TNFalpha treatment, and were unchanged following blockade of neuromuscular activity alone with alpha-bungarotoxin. Regardless of the direction of scaling, immediately following reversal of treatment no chronic effect was distinguishable in motoneuron activity patterns or in swimming behavior. We also acutely induced a similar increase of glutamatergic mPSC amplitudes using cyclothiazide to reduce AMPA receptor desensitization or decrease of glutamatergic mPSC amplitudes using a low concentration of CNQX to partially block AMPA receptors. Though the strength of the motor output was altered, neither chronic nor acute treatments disrupted the patterning of synaptic activity or swimming. Our results show, for the first time, that scaling of glutamatergic synapses can be induced in vivo in the zebrafish and that synaptic patterning is less plastic than synaptic strength during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.