ArticleJournal of clinical microbiology2010
Leukoencephalopathy associated with parvovirus infection in Cretan hound puppies.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- The canine blood-brain barrier in health and disease: focus on brain protection.The veterinary quarterly · 2025Review
- Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats.Metabolic brain disease · 2025Article
- Retrospective Analysis of Central Nervous System Diseases in Dogs, with Special Focus on Non-Suppurative Encephalomyelitis (1962-2022).Veterinary sciences · 2025Article
- The first outbreak of feline panleukopenia virus infection in captive Pallas's cats in Xining Wildlife Park.Frontiers in veterinary science · 2024Article
- Antimicrobial Resistance (AMR) of Bacteria Isolated from Dogs with Canine Parvovirus (CPV) Infection: The Need for a Rational Use of Antibiotics in Companion Animal Health.Antibiotics (Basel, Switzerland) · 2022Article
- Case Report: MRI, Clinical, and Pathological Correlates of Bromethalin Toxicosis in Three Dogs.Frontiers in veterinary science · 2022Article
- Pathogen Screening for Possible Causes of Meningitis/Encephalitis in Wild Carnivores From Saxony-Anhalt.Frontiers in veterinary science · 2022Article
- A hypomyelinating leukodystrophy in German Shepherd dogs.Journal of veterinary internal medicine · 2021Article
- Molecular and Pathological Investigations of Selected Viral Neuropathogens in Rabies-Negative Brains of Cats and Dogs Revealed Neurotropism of Carnivore Protoparvovirus-1.Frontiers in veterinary science · 2021Article
- Update on Canine Parvoviral Enteritis.The Veterinary clinics of North America. Small animal practice · 2020Review
- Evidence of Human Parvovirus B19 Infection in the Post-Mortem Brain Tissue of the Elderly.Viruses · 2018Article
- Comparison of DifferentViruses · 2018Article
- Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.The neuroradiology journal · 2018Article
- First molecular characterization of canine parvovirus strains in Sardinia, Italy.Archives of virology · 2017Article
- Novel region of interest interrogation technique for diffusion tensor imaging analysis in the canine brain.The neuroradiology journal · 2017Article
- Article
- Screening red foxes (Vulpes vulpes) for possible viral causes of encephalitis.Virology journal · 2016Article
- Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging.The neuroradiology journal · 2016Article
- Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention.Veterinary medicine (Auckland, N.Z.) · 2016Review
- Novel canine bocavirus strain associated with severe enteritis in a dog litter.Veterinary microbiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukoencephalopathies in dogs encompass presumably inherited conditions such as leukodystrophies, hypomyelination or spongiform degeneration, but other causes, such as virus infections and toxic or nutritional factors, might also play a contributory role. In this report, we provide evidence of parvovirus infection and replication in the brains of five 6-week-old Cretan hound puppies suffering from a puppy shaker syndrome and leukoencephalopathy. Although these puppies belonged to two different litters, they were closely related, tracing back two generations to the same sire. Histologically, a mild to moderate lymphohistiocytic meningitis, with focal lymphohistiocytic leukoencephalitis in two animals, and a mild to moderate vacuolation with myelin loss, mainly in the white matter of the cerebellum was detected. Vacuolation was also found in the corpus callosum, fimbria hippocampi, mesencephalon, capsula interna, basal ganglia, and hypothalamus. By immunohistology and in situ hybridization, either parvoviral antigen, DNA, mRNA, or replicative intermediate DNA were detected in the cerebellum, hippocampus, periventricular areas, corpus callosum, cerebral cortex, medulla oblongata, and spinal cord. Parvovirus antigen, DNA, and mRNA were present in cells of the outer granular layer of the cerebellum and in periventricular cells, most likely representing spongioblasts, glial cells, neurons, endothelial cells, occasional macrophages, and ependymal cells. Sequencing revealed canine parvovirus type 2 stretches. Thus, an association of parvovirus infection with the leukoencephalopathy seems likely, possibly facilitated by a genetic predisposition due to the mode of inbreeding in this particular dog breed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.