ArticleJournal of virology2010
The architecture and chemical stability of the archaeal Sulfolobus turreted icosahedral virus.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Probing the habitability of potential sulfuric acid rich subsurface lakes in Europa's ice shell viaFrontiers in microbiology · 2026Article
- Archaeal virus entry and egress.microLife · 2024Review
- Viruses of theFrontiers in microbiology · 2023Review
- Structures of enveloped virions determined by cryogenic electron microscopy and tomography.Advances in virus research · 2019Article
- The Minor Capsid Protein VP11 of Thermophilic Bacteriophage P23-77 Facilitates Virus Assembly by Using Lipid-Protein Interactions.Journal of virology · 2015Article
- Maximizing the potential of electron cryomicroscopy data collected using direct detectors.Journal of structural biology · 2013Article
- Functional interplay between a virus and the ESCRT machinery in archaea.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Insights into a viral lytic pathway from an archaeal virus-host system.Journal of virology · 2013Article
- Confessions of an icosahedral virus crystallographer.Microscopy (Oxford, England) · 2013Review
- Structure of Sputnik, a virophage, at 3.5-Å resolution.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structure and cell biology of archaeal virus STIV.Current opinion in virology · 2012Review
- Proteomic analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus infection.Journal of proteome research · 2012Article
- Global analysis of viral infection in an archaeal model system.Frontiers in microbiology · 2012Article
- Lipids of archaeal viruses.Archaea (Vancouver, B.C.) · 2012Review
- Viral life cycles captured in three-dimensions with electron microscopy tomography.Current opinion in virology · 2011Review
- The 2.3-angstrom structure of porcine circovirus 2.Journal of virology · 2011Article
- Sulfolobus turreted icosahedral virus c92 protein responsible for the formation of pyramid-like cellular lysis structures.Journal of virology · 2011Article
- The Prevalence of STIV c92-Like Proteins in Acidic Thermal Environments.Advances in virology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Viruses utilize a diverse array of mechanisms to deliver their genomes into hosts. While great strides have been made in understanding the genome delivery of eukaryotic and prokaryotic viruses, little is known about archaeal virus genome delivery and the associated particle changes. The Sulfolobus turreted icosahedral virus (STIV) is a double-stranded DNA (dsDNA) archaeal virus that contains a host-derived membrane sandwiched between the genome and the proteinaceous capsid shell. Using cryo-electron microscopy (cryo-EM) and different biochemical treatments, we identified three viral morphologies that may correspond to biochemical disassembly states of STIV. One of these morphologies was subtly different from the previously published 27-A-resolution electron density that was interpreted with the crystal structure of the major capsid protein (MCP). However, these particles could be analyzed at 12.5-A resolution by cryo-EM. Comparing these two structures, we identified the location of multiple proteins forming the large turret-like appendages at the icosahedral vertices, observed heterogeneous glycosylation of the capsid shell, and identified mobile MCP C-terminal arms responsible for tethering and releasing the underlying viral membrane to and from the capsid shell. Collectively, our studies allow us to propose a fusogenic mechanism of genome delivery by STIV, in which the dismantled capsid shell allows for the fusion of the viral and host membranes and the internalization of the viral genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.