ArticleBiological research for nursing2010
Gene-environment interaction for hypertension among African American women across generations.
Article in Biological research for nursing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Identification of a genetic variant at 2q12.1 associated with blood pressure in East Asians by genome-wide scan including gene-environment interactions.BMC medical genetics · 2014Pooled it
- Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy.Obstetrics and gynecology · 2026Article
- Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study.Journal of human hypertension · 2025Article
- Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.Frontiers in cellular and infection microbiology · 2024Article
- Article
- Genetic Basis of Blood-Based Traits and Their Relationship With Performance and Environment in Beef Cattle at Weaning.Frontiers in genetics · 2020Article
- Omics for Nurse Scientists Conducting Environmental Health Research.Annual review of nursing research · 2019Article
- Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.Biological research for nursing · 2018Article
- Impact of Clinical Factors on the Achievement of Target Blood Pressure in Hypertensive Patients from Ivanovo Region of Russia: Data of 2015.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Article
- The Metabolic Syndrome and Its Components in African-American Women: Emerging Trends and Implications.Frontiers in endocrinology · 2017Review
- The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis.Biological research for nursing · 2016Article
- A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.Scientific reports · 2016Article
- A perspective for sequencing familial hypercholesterolaemia in African Americans.NPJ genomic medicine · 2016Article
- Genetic Loci and Novel Discrimination Measures Associated with Blood Pressure Variation in African Americans Living in Tallahassee.PloS one · 2016Article
- Body mass index modulates blood pressure heritability: the Family Blood Pressure Program.American journal of hypertension · 2014Article
- An overview of the genomics of metabolic syndrome.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2013Review
- Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.Biological research for nursing · 2013Article
- Attitudes toward Genetic Testing for Hypertension among African American Women and Girls.Nursing research and practice · 2013Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
African American women have the highest prevalence of hypertension and obesity of any group in the United States. African American girls have the highest incidence of obesity of any groups of children in the nation, and diagnoses of hypertension have been rising among this group. Because both genetic heredity and body mass index (BMI) are important risk factors for hypertension, this study examined the gene-BMI interaction for hypertension across the lifespan in two generations of African American women. Participants comprised of 868 African American women in the parent cohort and 322 in the offspring cohort from the Hypertension Genetic Epidemiology Network (HyperGEN) study, part of the Family Blood Pressure Program (FBPP). A total of 115 single-nucleotide polymorphisms (SNPs) were evaluated among the parent cohort and 491 among the offspring cohort for tests of SNP-BMI interaction using methods of false discovery rate (FDR; <.20) and examination of minor allele frequency (MAF; >.05) and Hardy-Weinberg equilibrium (>.10). One SNP (located in the CAPN 13 gene, rs1879282) passed adjustments for the multiple testing mentioned above and had a significant (p < .01) gene-BMI interaction on both systolic blood pressure (SBP) and diastolic blood pressure (DBP) among African American female offspring. The rs1879282 SNP is located on chromosome 2 on the calpain (CAPN) 13 gene, which is part of a family of cytosolic calcium-activated proteases involved in apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity. This SNP was not available for testing in the African American parent cohort.
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Registered trials
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