ArticleBiological psychiatry2010
A role for p11 in the antidepressant action of brain-derived neurotrophic factor.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 96 citations in OpenAlex.
- Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients.Neuropsychiatric disease and treatment · 2025Trial
- Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs.Molecular psychiatry · 2014Trial
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Expression of p11 in Patients with Depression.Journal of clinical medicine · 2022Article
- The role of serotonin neurotransmission in rapid antidepressant actions.Psychopharmacology · 2022Review
- S100A10 and its binding partners in depression and antidepressant actions.Frontiers in molecular neuroscience · 2022Review
- Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.Scientific reports · 2021Article
- Regulation of S100A10 Gene Expression.Biomolecules · 2021Article
- Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants.Molecular psychiatry · 2021Article
- P11 deficiency increases stress reactivity along with HPA axis and autonomic hyperresponsiveness.Molecular psychiatry · 2021Article
- Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy.Cancers · 2021Review
- Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice.International journal of molecular sciences · 2021Article
- Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors.Molecular neurobiology · 2020Article
- AP-1 controls the p11-dependent antidepressant response.Molecular psychiatry · 2020Article
- Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment.Molecular psychiatry · 2020Article
- Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects.Molecular psychiatry · 2020Article
- Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons.Molecular psychiatry · 2020Article
- GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness.Cells · 2020Review
- Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment.European archives of psychiatry and clinical neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe protein p11 (also called S100A10) is downregulated in human and rodent depressive-like states. Considerable experimental evidence also implicates p11 in the mechanism of action of antidepressant drugs and electroconvulsive seizures, in part due to its interaction with specific serotonin receptors. Brain-derived neurotrophic factor (BDNF) has been linked to the therapeutic activity of antidepressants in rodent models and humans. In the current study, we investigated whether BDNF regulates p11 in vitro and in vivo.
methodsWe utilized primary neuronal cultures, in vivo analyses of transgenic mice, and behavioral techniques to assess the effects of BDNF on p11.
resultsResults indicate that BDNF stimulates p11 expression through tropomyosin-related kinase B (trkB) receptors and via the mitogen-activated protein kinase signaling pathway. Brain-derived neurotrophic factor-induced changes in p11 in vivo correlate with changes in ligand binding to the 5-hydroxytryptamine receptor 1B, the subcellular localization of which is known to be regulated by p11. Behavioral studies demonstrate that p11 knockout mice are insensitive to the antidepressant actions of BDNF.
conclusionsTaken together, our data demonstrate that p11 levels are regulated by BDNF in vitro and in vivo and that the antidepressant-like effect of BDNF in two well-established behavioral models requires p11. These data support a role for p11 in the antidepressant activity of neurotrophins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.