ArticleReproduction, fertility, and development2010
Role of Fyn kinase in oocyte developmental potential.
Article in Reproduction, fertility, and development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Extracellular vesicles secreted by cumulus cells contain microRNAs that are potential regulatory factors of mouse oocyte developmental competence.Molecular human reproduction · 2024Article
- Signaling Proteins Recruited to the Sperm Binding Site: Role of β-Catenin and Rho A.Frontiers in cell and developmental biology · 2022Article
- Targeted whole exome sequencing and Drosophila modelling to unveil the molecular basis of primary ovarian insufficiency.Human reproduction (Oxford, England) · 2021Article
- Auxin-inducible protein degradation as a novel approach for protein depletion and reverse genetic discoveries in mammalian oocytes†.Biology of reproduction · 2019Article
- Regulation of GVBD in mouse oocytes by miR-125a-3p and Fyn kinase through modulation of actin filaments.Scientific reports · 2017Article
- Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows.PloS one · 2017Article
- Article
- MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State in a Calcium- and Zinc-Dependent Manner.Biology of reproduction · 2015Article
- Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants.Molecular human reproduction · 2015Article
- Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis.Molecular reproduction and development · 2014Article
- PTK2b function during fertilization of the mouse oocyte.Biochemical and biophysical research communications · 2014Article
- SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective.Advances in experimental medicine and biology · 2014Review
- Intersecting roles of protein tyrosine kinase and calcium signaling during fertilization.Cell calcium · 2013Review
- PYK2: a calcium-sensitive protein tyrosine kinase activated in response to fertilization of the zebrafish oocyte.Developmental biology · 2013Article
- Role of FYN kinase in spermatogenesis: defects characteristic of Fyn-null sperm in mice.Biology of reproduction · 2012Article
- C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Advances in experimental medicine and biology · 2012Article
- The spatial and mechanical challenges of female meiosis.Molecular reproduction and developmentReview
- Protein tyrosine kinase signaling during oocyte maturation and fertilization.Molecular reproduction and developmentReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Fyn kinase is highly expressed in oocytes, with inhibitor and dominant-negative studies suggesting a role in the signal transduction events during egg activation. The purpose of the present investigation was to test the hypothesis that Fyn is required for calcium signalling, meiosis resumption and pronuclear congression using the Fyn-knockout mouse as a model. Accelerated breeding studies revealed that Fyn-null females produced smaller litter sizes at longer intervals and exhibited a rapid decline in pup production with increasing age. Fyn-null females produced a similar number of oocytes, but the frequency of immature oocytes and mature oocytes with spindle chromosome abnormalities was significantly higher than in controls. Fertilised Fyn-null oocytes frequently (24%) failed to undergo pronuclear congression and remained at the one-cell stage. Stimulation with gonadotropins increased the number of oocytes ovulated, but did not overcome the above defects. Fyn-null oocytes overexpressed Yes kinase in an apparent effort to compensate for the loss of Fyn, yet still exhibited an altered pattern of protein tyrosine phosphorylation. In summary, Fyn-null female mice exhibit reduced fertility that appears to result from actin cytoskeletal defects rather than calcium signalling. These defects cause developmental arrest during oocyte maturation and pronuclear congression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.